17β-Hydroxysteroid dehydrogenases involved in local oestrogen synthesis have prognostic significance in breast cancer
17β-Hydroxysteroid dehydrogenases involved in local oestrogen synthesis have prognostic significance in breast cancer
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DOI：
10.1038/sj.bjc.6602375
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发表时间：
2005-02-14
影响因子：
8.8
通讯作者：
Stål, O
中科院分区：
文献类型：
--
作者：
Gunnarsson, C;Hellqvist, E;Stål, O
17 β羟基类固醇脱氢酶（17 HSD）参与性类固醇的局部调节。17 HSD 1型酶催化弱雌酮（E1）转化为更有效的雌二醇（E2），而17 HSD 2型酶催化E2氧化为E1。这项研究的目的是将这些酶在肿瘤中的表达与他莫昔芬治疗的乳腺癌患者的无复发生存率相关联。我们使用真实的-时间逆转录酶PCR研究17 HSD 1型和2型在230例绝经后患者的肿瘤样本中的mRNA表达。对于雌激素受体（ER）阳性乳腺癌患者，我们发现无复发生存率与17 HSD 2型表达之间存在统计学显著正相关（P = 0.026）。我们检查了17例HSD 2型和1型的比率，低比率的ER阳性患者的复发率显著高于高比率的患者（P = 0.0047）。ER阳性患者中17 HSD 1型高表达者晚期复发的风险显著增高（P = 0.0051）。17 HSD 1型和2型在乳腺癌中的表达与这些酶在正常乳腺中的表达不同，本研究表明，17 HSD 1型和2型的表达在乳腺癌中具有预后意义。
The 17beta hydroxysteroid dehydrogenase ( 17HSD) enzymes are involved in the local regulation of sex steroids. The 17HSD type 1 enzyme catalyses the interconversion of the weak oestrone ( E1) to the more potent oestradiol ( E2), whereas 17HSD type 2 catalyses the oxidation of E2 to E1. The aim of this study was to correlate the expression of these enzymes in the tumour with the recurrence- free survival of tamoxifen- treated breast cancer patients. We used real- time reverse transcriptase PCR to investigate the mRNA expression of 17HSD types 1 and 2 in tumour samples from 230 postmenopausal patients. For the patients with oestrogen receptor ( ER)- positive breast cancer, we found a statistically significant positive correlation between recurrence- free survival and expression of 17HSD type 2 ( P = 0.026). We examined the ratio of 17HSD types 2 and 1, and ER- positive patients with low ratios showed a significantly higher rate of recurrence than those with higher ratios ( P = 0.0047). ER positive patients with high expression levels of 17HSD type 1 had a significantly higher risk for late relapse ( P = 0.0051). The expression of 17HSD types 1 and 2 in breast cancer differs from the expression of these enzymes in normal mammary gland, and this study indicates that the expression has prognostic significance in breast cancer.