(-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists.
(-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists.
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(-)-Propranolol 可阻断 5-HT1A 选择性激动剂对血清素能中缝背细胞放电的抑制。
DOI：
10.1016/0014-2999(86)90782-x
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发表时间：
1986
影响因子：
5
通讯作者：
Aghajanian,GK
中科院分区：
文献类型：
--
作者：
Sprouse,JS;Aghajanian,GK
用β-肾上腺素能受体拮抗剂普萘洛尔阻断5-羟色胺（5-HT）和5-HT_（1A）选择性激动剂对中缝背核神经元自发放电的影响。在微离子电渗疗法应用过程中，（-）-普萘洛尔而不是（+）-普萘洛尔可快速可逆地阻断5-HT 1A选择性激动剂伊沙匹隆（TVX Q 7821）和8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）的抑制作用。而（-）-普萘洛尔本身对5-HT的拮抗作用较弱，提示内源性神经递质对中缝背核神经元的作用可能是5-HT_（1A）受体介导的。
The ability of the β-adrenoceptor antagonist propranolol to block the effects of serotonin (5-HT) and 5-HT1A-selective agonists on the spontaneous firing of serotonergic dorsal raphe neurons was assessed. During microiontophoretic application, (-)- but not (+)-propranolol rapidly and reversibly blocked the suppressant effects of the 5-HT1A-selective agonists ipsapirone (TVX Q 7821) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). However, (-)-propranolol was a relatively weak antagonist of 5-HT itself, suggesting that the endogenous neurotransmitter may have actions on dorsal raphe neurons in addition to those mediated by 5-HT1Areceptors.