Development of a rapid screening method to determine primary aromatic amines in kitchen utensils using direct analysis in real time mass spectrometry (DART-MS)
Development of a rapid screening method to determine primary aromatic amines in kitchen utensils using direct analysis in real time mass spectrometry (DART-MS)
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DOI：
10.1080/19440049.2013.867366
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发表时间：
2014-03-04
影响因子：
2.9
通讯作者：
Begley, T. H.
中科院分区：
文献类型：
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作者：
Paseiro-Cerrato, R.;Noonan, G. O.;Begley, T. H.
伯芳胺(PAAS)是一组对健康有不良影响的物质，用于各种商业产品。最近的几项研究使用了一些筛选和确认方法，报告了PAAS从一些厨房用具迁移到3%(w/v)的醋酸中。其中许多方法需要大量的样品制备，因此这项工作的目的是确定实时直接分析质谱仪(DART-MS)是否可以用作快速筛查工具来测定厨房用具中的PaaS。将直接分析器皿的DART-MS结果与超高效液相色谱串联质谱(UPLC-MS/MS)的PAA迁移结果进行了比较。UPLC-MS/MS方法线性好，灵敏度适中(LOD1.5mgl(-1)，LOQ4.5mgl(-1))，重复性2.4~13.2%，回收率可接受。DART-MS结果与UPLC-MS/MS数据吻合良好，100%的不符合(PAA阳性)样品被DART-MS成功鉴定。
Primary aromatic amines (PAAs) are a group of substances with undesirable health effects, that are used in a variety of commercial products. Several recent studies, using a number of screening and confirmatory methods, have reported the migration of PAAs from some kitchen utensils into acetic acid 3% (w/v). Many of these methods require significant sample preparation, therefore the aim of this work was to determine if direct analysis in real time mass spectrometry (DART-MS) could be utilised as a rapid screening tool for the determination of PAAs in kitchen utensils. DART-MS results from direct analysis of the utensil have been compared with results of PAA migration by ultra high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method. The UPLC-MS/MS method had excellent linearity, appropriate sensitivity (LOD1.5 mu gL(-1); LOQ4.5 mu gL(-1)), repeatability from 2.4 to 13.2% and acceptable recoveries. DART-MS results were in good agreement with UPLC-MS/MS data, with 100% of non-compliant (PAA positive) samples successfully identified by DART-MS.