Reward-Related Activity in Ventral Striatum Is Action Contingent and Modulated by Behavioral Relevance
Reward-Related Activity in Ventral Striatum Is Action Contingent and Modulated by Behavioral Relevance
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DOI：
10.1523/jneurosci.4389-13.2014
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发表时间：
2014-01-22
影响因子：
5.3
通讯作者：
Dolan, Raymond J.
中科院分区：
文献类型：
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作者：
FitzGerald, Thomas H. B.;Schwartenbeck, Philipp;Dolan, Raymond J.
环境的多个特征往往具有激励意义，这些特征的相对重要性可能会因环境而异。能够灵活地调整评估过程，以便当前环境的重要特征单独驱动行为，这对适应性例程至关重要。我们对其中涉及的神经机制知之甚少，包括是否必须对具有激励意义的重要特征进行评估，或者当前的相关性是否会导致进入价值敏感区域。我们使用功能磁共振成像数据和任务设计来解决这些问题，在任务设计中，人类受试者必须选择接受或拒绝视觉和听觉刺激指示的提议。通过在逐个试验的基础上操纵哪些刺激决定了要约的价值，我们了解了腹侧纹状体的选择活动如何只反映当前相关刺激的价值，这与行为相关性调节感觉刺激对价值加工的影响的模型是一致的。在同一区域，选择结果信号与接受试验中的胜利呈正相关，与拒绝试验中的胜利呈负相关，与反映反应正确性的反馈纹状体活动一致，而不是奖赏加工本身。我们得出的结论是，决策过程中腹侧纹状体的活动受到行为背景的动态调节，这里以任务相关性和动作选择为指标。
Multiple features of the environment are often imbued with motivational significance, and the relative importance of these can change across contexts. The ability to flexibly adjust evaluative processes so that currently important features of the environment alone drive behavior is critical to adaptive routines. We know relatively little about the neural mechanisms involved, including whether motivationally significant features are obligatorily evaluated or whether current relevance gates access to value-sensitive regions. We addressed these questions using functional magnetic resonance imaging data and a task design where human subjects had to choose whether to accept or reject an offer indicated by visual and auditory stimuli. By manipulating, on a trial-by-trial basis, which stimulus determined the value of the offer, weshow choice activity in the ventral striatum solely reflects the value of the currently relevant stimulus, consistent with a model wherein behavioral relevance modulates the impact of sensory stimuli on value processing. Choice outcome signals in this same region covaried positively with wins on accept trials, and negatively with wins on reject trials, consistent with striatal activity at feedback reflecting correctness of response rather than reward processing per se. We conclude that ventral striatum activity during decision making is dynamically modulated by behavioral context, indexed here by task relevance and action selection.