Perceived Weight Discrimination Mediates the Prospective Association Between Obesity and Physiological Dysregulation: Evidence From a Population-Based Cohort
Perceived Weight Discrimination Mediates the Prospective Association Between Obesity and Physiological Dysregulation: Evidence From a Population-Based Cohort
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DOI：
10.1177/0956797619849440
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发表时间：
2019-07-01
影响因子：
8.2
通讯作者：
Robinson, Eric
中科院分区：
文献类型：
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作者：
Daly, Michael;Sutin, Angelina R.;Robinson, Eric
肥胖被认为会导致不健康，因为过量的脂肪会对生理功能产生生物压力。我们在基于人群的3609名英国老年人样本中测试了另一种解释-超重个人所经历的普遍歧视可能在一定程度上解释了为什么肥胖与随后的多系统生理失调有关，这是通过心血管、代谢和免疫功能的临床指标来衡量的。我们发现，肥胖和感知体重歧视都预示着从基线到4年后的随访，生理失调的发生率会增加。肥胖者由于体重而感受到的歧视，解释了肥胖症和健康状况生物标志物恶化之间预期联系的四分之一以上。这些发现突显了肥胖者经历的耻辱可能在解释肥胖相关疾病负担方面发挥重要作用的可能性。
Obesity is thought to cause ill health because of the biological strain that excess fat has on physiological function. We tested an alternative explanation in a population-based sample of 3,609 older English adults-that the pervasive discrimination experienced by individuals with excess weight may in part explain why obesity is associated with subsequent multisystem physiological dysregulation, measured via clinical indicators of cardiovascular, metabolic, and immune function. We found that both obesity and perceived weight discrimination predicted an increase in physiological dysregulation from baseline to follow-up 4 years later. Perceived discrimination because of body weight experienced by individuals with obesity explained more than one quarter of the prospective association between obesity and a deterioration in biomarkers of health status. These findings highlight the possibility that the stigma experienced by individuals with obesity may play an important role in explaining the obesity-related disease burden.