Mesenchymal stem cells: key players in cancer progression.
Mesenchymal stem cells: key players in cancer progression.
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DOI：
10.1186/s12943-017-0597-8
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发表时间：
2017-02-01
期刊：
影响因子：
37.3
通讯作者：
Glynn SA
中科院分区：
文献类型：
--
作者：
Ridge SM;Sullivan FJ;Glynn SA
肿瘤进展取决于肿瘤细胞与周围微环境细胞之间的相互作用。肿瘤是由各种细胞类型组成的动态环境，例如内皮细胞、成纤维细胞、免疫系统细胞和间充质干细胞（MSC）。间充质干细胞是多能基质细胞，已知其存在于各种区域，如骨髓、脂肪和牙髓。已经发现MSC向炎症部位迁移，并且研究表明它们也向肿瘤迁移并并入肿瘤中。关键问题是他们如何在那里互动。间充质干细胞可以通过旁分泌信号与肿瘤细胞相互作用。另一方面，MSC具有分化成各种细胞类型如骨细胞、软骨细胞和脂肪细胞的能力，并且MSC有可能在肿瘤部位分化。最近已经表明，肿瘤细胞和MSC之间的串扰已经显示出增加转移潜力并促进上皮向间充质转化。这篇综述将集中于骨髓间充质干细胞在肿瘤发展的各个阶段的作用，从原发性肿瘤的生长到远处转移的建立。
Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells, fibroblasts, cells of the immune system and mesenchymal stem cells (MSCs). MSCs are multipotent stromal cells that are known to reside in various areas such as the bone marrow, fat and dental pulp. MSCs have been found to migrate towards inflammatory sites and studies have shown that they also migrate towards and incorporate into the tumour. The key question is how they interact there. MSCs may interact with tumour cells through paracrine signalling. On the other hand, MSCs have the capacity to differentiate to various cell types such as osteocytes, chondrocytes and adipocytes and it is possible that MSCs differentiate at the site of the tumour. More recently it has been shown that cross-talk between tumour cells and MSCs has been shown to increase metastatic potential and promote epithelial-to-mesenchymal transition. This review will focus on the role of MSCs in tumour development at various stages of progression from growth of the primary tumour to the establishment of distant metastasis.