WNT-5A: signaling and functions in health and disease.
WNT-5A: signaling and functions in health and disease.
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DOI：
10.1007/s00018-015-2076-y
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Gosens R
中科院分区：
文献类型：
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作者：
Kumawat K;Gosens R
WNT-5A在从胚胎形态发生到维持出生后体内平衡的无数过程中起着关键作用。WNT-5A基因敲除小鼠不能存活，并出现广泛的结构畸形。WNT-5A主要激活β-连环蛋白非依赖性WNT信号传导级联，但也可以激活β-连环蛋白信号传导以传递其多种细胞效应，如细胞极性、迁移、增殖、细胞存活和免疫调节。此外，异常的WNT-5A信号传导与几种人类病理学相关，如癌症、纤维化和炎症。因此，由于其多样的功能，WNT-5A是一个重要的信号分子，目前正在进行深入研究，不仅努力描绘其信号传导机制和生理和病理条件下的功能，而且还开发其治疗靶向的策略。
WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present extensive structural malformations. WNT-5A predominantly activates β-catenin-independent WNT signaling cascade but can also activate β-catenin signaling to relay its diverse cellular effects such as cell polarity, migration, proliferation, cell survival, and immunomodulation. Moreover, aberrant WNT-5A signaling is associated with several human pathologies such as cancer, fibrosis, and inflammation. Thus, owing to its diverse functions, WNT-5A is a crucial signaling molecule currently under intense investigation with efforts to not only delineate its signaling mechanisms and functions in physiological and pathological conditions, but also to develop strategies for its therapeutic targeting.