Partitioning of pulmonary resistance during constriction in the dog: effects of volume history.
Partitioning of pulmonary resistance during constriction in the dog: effects of volume history.
复制标题
狗收缩期间肺阻力的划分：容量历史的影响。
DOI：
10.1152/jappl.1987.62.2.807
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
IngramJr,RH
中科院分区：
文献类型：
--
作者：
Ludwig,MS;Dreshaj,I;Solway,J;Munoz,A;IngramJr,RH
我们评估了支气管收缩时气道和肺组织的相对变化，以及深吸气（DI）期间和之后的变化。我们分区肺阻力（RL）到气道（Raw）和组织（Vtis）组件使用肺泡胶囊在10麻醉，麻痹，开胸犬在1Hz的350毫升的呼吸，以正弦通气。我们在迷走神经刺激或吸入组胺或前列腺素F2 α（PGF2 α）诱导支气管收缩之前和期间进行了测量，每种方法均使动态顺应性降低约40%。使用组胺和PGF2 α时，RL升高主要是由于Vtis。迷走神经刺激有一个相对较大的增加，在原始比Vtis。在较高的肺容量下，Vtis增加抵消Raw的福尔斯下降，在PGF 2 α和组胺收缩之前和期间在这些容量下产生较高的RL。在迷走神经刺激收缩期间，Raw随充气的下降超过了Vtis的上升，导致与较低肺容量相比，较高肺容量的RL较低。在对照和收缩状态下DI后观察到的变化是由于组织性质（粘性和弹性）的改变。然而，气道和实质的相对滞后是相等的，因为我们的气道大小指数Raw在DI后没有变化。
We assessed the relative changes in airways and lung tissue with bronchoconstriction, and the changes in each during and following a deep inhalation (DI). We partitioned pulmonary resistance (RL) into airway (Raw) and tissue (Vtis) components using alveolar capsules in 10 anesthetized, paralyzed, and open-chested dogs ventilated sinusoidally with 350-ml breaths at 1 Hz. We made measurements before and during bronchoconstriction induced by vagal stimulation or inhalation of histamine or prostaglandin F2 alpha (PGF2 alpha), each of which decreased dynamic compliance by approximately 40%. With histamine and PGF2 alpha the rise in RL was predominantly due to Vtis. With vagal stimulation there was a relatively greater increase in Raw than Vtis. At higher lung volumes, Vtis increases offset falls in Raw, producing higher RL at these volumes before and during constriction with PGF2 alpha and histamine. During constriction with vagal stimulation, the fall in Raw with inflation overrode the rise in Vtis, resulting in a lower RL at the higher compared with the lower lung volume. The changes seen after a DI in the control and constricted states were due to alterations in tissue properties, both viscous and elastic. However, the relative hysteresis of the airways and parenchyma were equal, since Raw, our index of airway size, was unchanged after a DI.