Clinical characteristics of acute respiratory syndrome with SARS-CoV-2 infection in children in South China
Clinical characteristics of acute respiratory syndrome with SARS-CoV-2 infection in children in South China
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DOI：
10.1002/ppul.24921
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发表时间：
2020-07-03
影响因子：
3.1
通讯作者：
Guo, Yuxiong
中科院分区：
文献类型：
--
作者：
Zheng, Guilang;Wang, Bangqin;Guo, Yuxiong
背景本研究对严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）流行期间儿童感染的临床资料进行回顾性分析。方法选取中国南方3省11家医院SARS CoV-2感染患儿为研究对象。收集临床资料，并与武汉地区SARS-CoV-2感染的儿童和成人进行比较。结果52例患儿中，男28例。中位年龄为9岁（四分位距[IQR]，4-12）; 44.2%的病例为聚集性发生，40.4%的患者有发热，48.1%有咳嗽，46.2%有高淋巴细胞计数。肝肾功能未见异常。此外，82.7%的患者接受了抗病毒治疗，但这种治疗并没有缩短病毒呈阴性或住院时间（P = 0.082）。至病毒阴性的时间为12.0天（IQR，8.0-16.8），住院时间为14.5天（IQR，10.3-17.9）。与武汉报告相比，急性上呼吸道感染（AURTI）较多，肺炎病例较少（P = 0.000）。与武汉非ICU成人COVID-19相比，这些儿童的疾病相对较轻，并发症较少。结论SARS-CoV-2感染患儿发热轻微，淋巴细胞升高多于减少，抗病毒治疗效果不明显。总体临床表现较轻，预后良好。
Background A retrospective study was conducted to summarize the clinical information of childhood infections during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic. Methods Children with SARS-CoV-2 infection in 11 hospitals from three provinces of South China were included in the study. Clinical information was collected and compared with children and adults infected by SARS-CoV-2 in Wuhan. Results In total, 52 children were enrolled, including 28 boys. The median age was 9 years (interquartile range [IQR], 4-12); 44.2% cases were of clustered occurrences, 40.4% patients had fever, 48.1% had cough, and 46.2% had a high lymphocyte count. No abnormalities were found in the liver and kidney function. Also, 82.7% of patients received antiviral therapy, but such therapy did not shorten the time to virus negativity or hospital stay (P = .082). The time to virus negativity was 12.0 days (IQR, 8.0-16.8) and hospital stay was 14.5 days (IQR, 10.3-17.9). Compared with reports in Wuhan, there were more acute upper respiratory tract infection (AURTI) and fewer pneumonia cases (P = .000). Compared with the non-ICU adult COVID-19 in Wuhan, these children's diseases were relatively mild, with fewer complications. Conclusions Children with SARS-CoV-2 infection had a mild fever, lymphocyte elevation was more common than reduction, and antiviral treatment had no obvious effect. The overall clinical manifestations were mild, and the prognosis was good.