IMMUNOCYTOCHEMICAL DEMONSTRATION OF NEUROPEPTIDES AND SEROTONIN IN THE NERVOUS-SYSTEM OF ADULT SCHISTOSOMA-MANSONI
IMMUNOCYTOCHEMICAL DEMONSTRATION OF NEUROPEPTIDES AND SEROTONIN IN THE NERVOUS-SYSTEM OF ADULT SCHISTOSOMA-MANSONI
复制标题
DOI：
10.1007/bf00536029
复制
发表时间：
1987-01-01
影响因子：
2
通讯作者：
GUSTAFSSON, MKS
中科院分区：
文献类型：
--
作者：
GUSTAFSSON, MKS
本文用免疫细胞化学方法研究了曼氏血吸虫成虫神经系统中神经肽和5-羟色胺的分布。在中枢和外周神经系统中发现了对抗FMRF-酰胺、抗P物质、抗亮氨酸脑啡肽和抗生长激素释放因子免疫反应的神经元和神经纤维。双叶脑中的肽能神经细胞体较大，通常为多极;外周神经网中的肽能神经细胞体较小，通常为双极。沿虫体表面沿着发现两种形态不同的感觉感受器。它们主要与抗P物质和抗亮脑啡肽呈免疫反应性，与抗FMRF-酰胺呈较低程度的免疫反应性。5-羟色胺免疫反应纤维存在于中枢和外周神经元以及感觉末梢。
In the nervous system of adult Schistosoma mansoni, neuropeptides and serotonin were demonstrated immunocytochemically. Neurons and nerve fibers immunoreactive to anti-FMRF-amide, anti-substance P, anti-leu-enkephalin, and anti-growth hormone releasing factor were found in the central and peripheral nervous system. The peptidergic nerve cell bodies in the bilobed brain are large and often multipolar; those in the peripheral nerve net are smaller and often bipolar. Sensory receptors of two morphologically different types were found along the surface of the worm. They are mainly immunoreactive to anti-substance P and anti-leu-enkephalin, and, to a lesser degree, to anti-FMRF-amide. Serotonin-immunoreactive fibers are found in the central and peripheral nervous elements as well as in sensory endings.