Prevalence of Depressive Disorders in Individuals with Autism Spectrum Disorder: a Meta-Analysis
Prevalence of Depressive Disorders in Individuals with Autism Spectrum Disorder: a Meta-Analysis
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DOI：
10.1007/s10802-018-0402-1
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发表时间：
2019-01-01
影响因子：
3.6
通讯作者：
Harkness, Kate L.
中科院分区：
文献类型：
--
作者：
Hudson, Chloe C.;Hall, Layla;Harkness, Kate L.
自闭症谱系障碍（ASD）患者抑郁障碍的患病率存在很大的不确定性。这项荟萃分析定量总结了评估儿童、青少年和成人ASD患者中单相抑郁障碍的终生和当前患病率的研究。我们还检查了人口统计学，方法学和研究主持人。这项荟萃分析遵循PRISMA指南。通过5个数据库（PubMed、Web of Science、PYSCInfo、CINAHL、ProQuest Dissertations and Theses）、前向检索和后向检索，共识别出7857篇文章。两名评审员独立筛选文章并提取数据。66篇文章符合纳入标准。结果表明，合并的终生患病率和当前患病率分别为14.4%（95%CI 10.3-19.8）和12.3%（95%CI 9.7-15.5）。在使用标准化访谈评估抑郁症的研究中，抑郁症的发病率最高（终生= 28.5%，95% CI 20.1-38.8;当前= 15.3%，95% CI 11.0-20.9），并要求参与者报告自己的抑郁症状（寿命= 48.6%，95% CI 33.3-64.2;当前= 25.9%，95% CI 17.0-37.3）。在包括智力较高的参与者的研究中，比率也更高。终生患病率与年龄和白色样本比例呈正相关，但与当前患病率无关。总之，我们发现ASD患者中抑郁症的发病率很高。与正常发育的个体相比，ASD患者一生中患抑郁症的可能性是正常人的4倍。这些结果表明，ASD患者应定期进行筛查，并提供抑郁症治疗。
Substantial uncertainty exists about the prevalence of depressive disorders in individuals with autism spectrum disorder (ASD). This meta-analysis quantitatively summarized studies that assessed the lifetime and current prevalence of unipolar depressive disorders in children, adolescents, and adults with ASD. We also examined demographic, methodological, and study moderators. This meta-analysis adhered to PRISMA guidelines. A total of 7857 articles were identified through 5 databases (PubMed, Web of Science, PYSCInfo, CINAHL, ProQuest Dissertations and Theses), forward searches, and backward searches. Two reviewers independently screened articles and extracted data. Sixty-six articles met inclusion criteria. Results indicated that the pooled lifetime and current prevalence was 14.4% (95% CI 10.3-19.8) and 12.3% (95% CI 9.7-15.5), respectively. Rates of depressive disorders were highest among studies that used a standardized interview to assess depressive disorders (lifetime=28.5%, 95% CI 20.1-38.8; current=15.3%, 95% CI 11.0-20.9) and required participants to report on their own depressive symptoms (lifetime=48.6%, 95% CI 33.3-64.2; current=25.9%, 95% CI 17.0-37.3). Rates were also higher in studies that included participants with higher intelligence. Lifetime, but not current, prevalence was positively associated with age and the proportion of the sample that was White. In conclusion, we found that the rates of depressive disorders are high among individuals with ASD. Compared to typically developing individuals, individuals with ASD are 4-times more likely to experience depression in their lifetime. These results suggest that individuals with ASD should be regularly screened and offered treatment for depression.