Polymorphonuclear Leukocyte Adherence and Chemotaxis in Stressed and Healthy Neonates
Polymorphonuclear Leukocyte Adherence and Chemotaxis in Stressed and Healthy Neonates
复制标题
应激和健康新生儿的多形核白细胞粘附和趋化性
作者：
P. Krause;V. Herson;Jocelyne Boutin;L. Eisenfeld;C. Block;Tina M. LoBello;E. Maderazo
摘要。新生儿中性粒细胞（PMN）粘附和趋化性缺陷被认为是其对细菌感染易感性增加的重要原因。很少有关于这些功能的研究在有更大感染风险的应激新生儿中进行。采用全血中性粒细胞粘附和趋化性测定法，对33例急性下呼吸道疾病应激新生儿、13例健康新生儿和43例健康成人的中性粒细胞粘附和趋化性进行了检测。与健康新生儿（48.9 ± 12.8 µm，p<0.01）或成人（61.6 ± 11.9 µm，p<0.001）相比，应激新生儿（运动指数为38.4 ± 9.7 µm）的PMN趋化性显著降低。研究了33例应激新生儿中13例在患病和恢复期间的PMN趋化性，结果显示在恢复期间PMN趋化性显著改善（分别为41.6 ± 9.9和53.2 ± 11.9 µm，p = 0.012）。应激新生儿PMN粘附率（1.4 ± 1.6%）低于成人（12.3 ± 11.4%，P<0.01），但与健康新生儿（1.1 ± 1.4%）相似。这些结果表明，进一步损害中性粒细胞趋化性在强调新生儿有助于解释他们的易感性增加压倒性的细菌感染。
ABSTRACT. Defects in polymorphonuclear neutrophil (PMN) adherence and chemotaxis in neonates are thought to be an important cause of their increased susceptibility to overwhelming bacterial infection. Few studies of these functions have been carried out in stressed neonates who are at even greater risk of infection. PMN adherence and chemotaxis were examined in 33 stressed neonates with acute lower respiratory illness, 13 healthy neonates, and 43 healthy adults using whole blood PMN adherence and chemotaxis assays. PMN chemotaxis was significantly decreased in stressed neonates (locomotion index of 38.4 ± 9.7 µm) compared with that of healthy neonates (48.9 ± 12.8 µm, p<0.01) or adults (61.6 ± 11.9 µm, p<0.001). PMN chemotaxis was studied during illness and recovery in 13 of the 33 stressed neonates and showed significant improvement during recovery (41.6 ± 9.9 and 53.2 ± 11.9 µm, respectively, p = 0.012). PMN adherence was decreased in stressed neonates (1.4 ± 1.6%) compared with that of adults (12.3 ± 11.4%, p<0.01) but was similar to that of healthy neonates (1.1 ± 1.4%). These findings suggest that further impairment of PMN chemotaxis in stressed neonates helps account for their increased susceptibility to overwhelming bacterial infection.
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针对中性粒细胞亚群的抗体表现出与反应异质性相关的抗原异质性。
DOI：
--
发表时间：
1984
期刊：
Transactions of the Association of American Physicians
影响因子：
--
作者：
Seligmann,B;Malech,HL;Melnick,DA;Gallin,JI
通讯作者：
Gallin,JI
影响因子：
9.6
作者：
B. Ogden;S. Murphy;G. Saunders;J. Johnson
通讯作者：
B. Ogden;S. Murphy;G. Saunders;J. Johnson
与人中性粒细胞结合的抗体表现出在骨髓成熟早期检测到的抗原异质性，这与成熟中性粒细胞的功能异质性相关。
DOI：
--
发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Seligmann,B;Malech,HL;Melnick,DA;Gallin,JI
通讯作者：
Gallin,JI
影响因子：
15.9
作者：
ANDERSON, DC;SCHMALSTIEG, FC;SMITH, CW
通讯作者：
SMITH, CW