The manner of metabolism is different between the atrium and the ventricle
The manner of metabolism is different between the atrium and the ventricle
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DOI：
10.1096/fasebj.26.1_supplement.1144.18
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发表时间：
2012-04
期刊：
影响因子：
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通讯作者：
D. Shimura;Q. Jiao;Kasumi Kashikura;Keiko Endo;T. Soga;N. Goda;S. Minamisawa
中科院分区：
文献类型：
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作者：
D. Shimura;Q. Jiao;Kasumi Kashikura;Keiko Endo;T. Soga;N. Goda;S. Minamisawa
心肌的能量在很大程度上取决于脂肪酸氧化（FAO）。众所周知，心房和心室具有组织特异性的功能、结构、基因表达和病理。心室泵血，其肌壁比心房壁厚。因此，它们之间的能源利用应该是不同的。然而，心脏代谢的组织特异性模式仍然不完全清楚。最近，创新技术使得对代谢物的综合分析成为可能。因此，我们为明确心房和心室的差异，以6周龄雄性C57B6小鼠为研究对象，采用毛细管电泳和质谱法对其心房和心室代谢物进行综合测定。
Energy of the cardiac muscle largely depends on fatty acid oxidation (FAO). It is known that the atrium and the ventricle have tissue‐specific functions, structures, gene expressions, and pathologies. The ventricle pumps blood and its muscle wall is thicker than atrial wall. Thus, energy utilization should be different between them. However a tissue‐specific pattern of cardiac metabolism remains incompletely understood. Recently, innovative techniques have enabled comprehensive analysis of metabolites. Therefore, we aimed to clarify differences between the atrium and the ventricle and used male C57B6 mice at the age of 6 weeks to comprehensively measure metabolites of their atria and ventricles by capillary electrophoresis and mass spectrometry.