Charged Polymer Brushes-Grafted Hollow Silica Nanoparticles as a Novel Promising Material for Simultaneous Joint Lubrication and Treatment
Charged Polymer Brushes-Grafted Hollow Silica Nanoparticles as a Novel Promising Material for Simultaneous Joint Lubrication and Treatment
复制标题
带电聚合物刷接枝空心二氧化硅纳米粒子作为同步关节润滑和治疗的新型有前景材料
DOI：
10.1021/jp500074g
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发表时间：
2014-05-08
影响因子：
3.3
通讯作者：
Liu, Weimin
中科院分区：
文献类型：
--
作者：
Liu, Guoqiang;Cai, Meirong;Liu, Weimin
报道了核/壳带电聚合物电刷接枝中空二氧化硅纳米粒子（PSPMA-g-HSNPs）的制备。由于带电聚合物刷壳具有优异的水化性能，功能纳米颗粒可以通过水化润滑机制在水介质中获得良好的润滑效果。介孔空心二氧化硅核使纳米颗粒具有载药释放能力。阿司匹林作为一种治疗关节炎的有效药物，被用来进行体外药物负荷和释放研究。显然，电刷修饰的空心二氧化硅具有长期的药物释放性能。润滑和药物负载能力的结合导致了新的多功能纳米颗粒作为关节炎治疗中可注射关节润滑液的巨大临床潜力。
The fabrication of core/shell charged polymer brushes-grafted hollow silica nanoparticles (PSPMA-g-HSNPs) is reported. Because of the excellent hydration capability of the shells consisting of charged polymer brushes, the functional nanoparticles can achieve a good lubricating effect in aqueous media via hydration lubrication mechanism. The mesoporous hollow silica cores endow the nanoparticles with drug loading-release capability. Aspirin, as a useful drug for treating arthritis, was employed to carry out in vitro drug loading and release studies. It is clear that brushes-modified hollow silica exhibited long-term drug release performance. The combination of lubrication and drug loading capabilities results in the great clinical potential of new multifunctional nanoparticles as injectable joint lubricant fluid in arthritis treatment.