Modulite®:: a means of designing the aerosols generated by pressurized metered dose inhalers
Modulite®:: a means of designing the aerosols generated by pressurized metered dose inhalers
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DOI：
10.1016/s0954-6111(02)80018-x
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发表时间：
2002-08-01
影响因子：
4.3
通讯作者：
Church, T
中科院分区：
文献类型：
--
作者：
Ganderton, D;Lewis, D;Church, T
尽管很受欢迎，但加压计量吸入器会产生粗大、快速移动的云层，因此到达肺部的部分很小。MODULITE(R)可以改变以下变量：溶液配方的非挥发性成分、执行器孔口几何形状、计量溶液的体积和推进剂的蒸气压力。这允许设计具有选定的颗粒大小和羽流速度的气雾剂。这促进了剂量产生与吸入的协调，减少了口咽沉积，并提供了一种靶向将药物输送到肺不同部位的机制。这些原则通过设计一种氢氟烷烃推动的倍氯米松二丙酸酯产品来举例说明，该产品与使用氯氟烃的现有产品非常接近。(C)2002年爱思唯尔科学有限公司。
Although popular, the pressurized metered dose inhaler generates coarse, fast moving clouds so that the fraction reaching the lung is small. These shortcomings can be redressed by Modulite(R) which permutes the following variables: the non-volatile components of a solution formula, the actuator orifice geometry, the volume of the metered solution and the vapour pressure of the propellants. This permits the design of aerosols with chosen particle size and plume speed. This facilitates co-ordination of dose generation with inspiration, reduces oropharyngeal deposition and provides a mechanism for targeting drug delivery to different parts of the lung. These principles are exemplified by designing an HFA-propelled beclometasone dipropionate product which closely matches existing products which use chlorofluorocarbons. (C) 2002 Elsevier Science Ltd.