Systemic lupus erythematosus
Systemic lupus erythematosus
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DOI：
10.1016/s0140-6736(14)60128-8
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发表时间：
2014-11-22
期刊：
影响因子：
168.9
通讯作者：
Isenberg, David
中科院分区：
文献类型：
--
作者：
Lisnevskaia, Larissa;Murphy, Grainne;Isenberg, David
系统性红斑狼疮是一种显著的和具有挑战性的疾病。其临床特征的多样性与导致其的因素（遗传，激素和环境）的复杂性以及与其相关的自身抗体阵列相匹配。在本次研讨会上，我们反映了其分类标准的变化，考虑其更严重的临床表现方面，并提供了一个简短的回顾其病因，主要并发症，应对策略和常规治疗。对参与疾病发展的细胞和分子的了解的增加鼓励了对其治疗的新的、更有针对性的生物方法的鉴定。这些新疗法的确切作用仍有待确定。
Systemic lupus erythematosus is a remarkable and challenging disorder. Its diversity of clinical features is matched by the complexity of the factors (genetic, hormonal, and environmental) that cause it, and the array of autoantibodies with which it is associated. In this Seminar we reflect on changes in its classification criteria; consider aspects of its more serious clinical expression; and provide a brief review of its aetiopathogenesis, major complications, coping strategies, and conventional treatment. Increased understanding of the cells and molecules involved in the development of the diseases has encouraged the identification of new, better targeted biological approaches to its treatment. The precise role of these newer therapies remains to be established.