Relationship of leptin concentration to gender, menopause, age, diabetes, and fat mass in African Americans.
Relationship of leptin concentration to gender, menopause, age, diabetes, and fat mass in African Americans.
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DOI：
10.1002/j.1550-8528.1998.tb00326.x
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发表时间：
1998-03
期刊：
影响因子：
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通讯作者：
A. Sumner;B. Falkner;H. Kushner;R. Considine
中科院分区：
文献类型：
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作者：
A. Sumner;B. Falkner;H. Kushner;R. Considine
这项研究旨在确定非裔美国人中瘦素浓度与性别、性激素、绝经、年龄、糖尿病和脂肪量的关系。参与者包括101名非裔美国人，38名男性(平均年龄34.2±7.4岁)，29名年龄匹配的绝经前女性(平均年龄32.6±3.7岁)，以及36名绝经后女性(平均年龄57.8±5.9岁)。这些女性没有服用外源性性激素，12名受试者患有糖尿病。体脂百分比按Siri公式计算，脂肪质量(Fm)按体重x体脂百分比计算，脱脂质量(FFM)按体重减去Fm计算。测定空腹血浆中瘦素、雌二醇、游离睾酮、葡萄糖和胰岛素浓度。对非糖尿病患者进行口服葡萄糖耐量试验(OGTT)。糖尿病患者与非糖尿病患者相比，中心脂肪指数较高(p=0.04)，但其他各项指标与非糖尿病患者相似。女性的体重指数、体脂百分比和FM大于男性(p<；0.001)。男性、绝经前和绝经后女性的瘦素水平分别为：7.51±8.5、33.9±17.3、31.4±22.3 ng/mL。3组瘦素/FMx100分别为28.9+/-16.1、98.65+/-44.9、77.1+/-44.5 ng/mL/kg。瘦素浓度和瘦素/Fm的性别差异有统计学意义(p<；0.001)，但绝经前和绝经后妇女之间的差异无统计学意义。在每组中，体重、体脂百分比和FM与瘦素浓度高度相关。以瘦素浓度为因变量，以年龄、糖尿病状况、体脂百分比、体重、FM、FFM、雌二醇和游离睾酮浓度为自变量进行多元回归分析表明，男性瘦素浓度的决定因素仅为体重(R=0.83p<；0.001)，绝经前女性仅为FM(R=0.57p<；0.001)，绝经后女性仅为体重(R=0.67p<；0.001)。排除糖尿病患者后，以空腹胰岛素浓度和OGTT期间胰岛素曲线下面积为自变量进行多元回归分析。多元回归分析的结果与第一次相同。因此，非裔美国人的瘦素浓度是由性别和脂肪量决定的。绝经、年龄和糖尿病不影响瘦素浓度。
This investigation was designed to determine the relationship of leptin concentration to gender, sex hormones, menopause, age, diabetes, and fat mass in African Americans. Participants included 101 African Americans, 38 men (mean age, 34.2 +/- 7.4 years), 29 age-matched premenopausal women (mean age, 32.6 +/- 3.7 years), and 36 postmenopausal women (mean age, 57.8 +/- 5.9 years). The women were not taking exogenous sex hormones, and 12 subjects were diabetic. Percent body fat was calculated with the Siri formula, fat mass (FM) was calculated as weight x percent body fat, and Fat-free mass (FFM) was calculated as weight minus FM. Fasting plasma was assayed for leptin, estradiol, free testosterone, glucose, and insulin concentrations. The nondiabetics had an oral glucose tolerance test (OGTT). The diabetics compared with the non-diabetics had a higher central fat index (p=0.04) but otherwise were similar to nondiabetics in all parameters measured. Body mass index, percent body fat, and FM were greater in women than men (p<0.001). Leptin concentrations in men, premenopausal, and postmenopausal women were: 7.51 +/- 8.5, 33.9 +/- 17.3, 31.4 +/- 22.3 ng/mL. Leptin/FM x 100 in the three groups were: 28.9 +/- 16.1, 98.65 +/- 44.9, 77.1 +/- 44.5 ng/mL/kg. The gender difference in leptin concentration and leptin/FM was significant (p<0.001), but the difference between premenopausal and postmenopausal women was not. In each group, weight, percent body fat, and FM were highly correlated with leptin concentration. Multiple regression analyses with leptin concentration as the dependent variable and age, diabetic status, percent body fat, weight, FM, FFM, estradiol, and free testosterone concentrations as independent variables demonstrated that the determinants of leptin concentration in men was weight only (R=0.83, p<0.001), in premenopausal women it was FM only (R=0.57, p<0.001), and in postmenopausal women it was weight only (R=0.67, p<0.001). With diabetics excluded, the multiple regression analysis was repeated with fasting insulin concentration and the area under the insulin curve during the OGTT included as independent variables. The results for this multiple regression analyses were the same as the first. Therefore, leptin concentration in African Americans is determined by gender and fat mass. Menopause, age, and diabetes do not affect leptin concentration.