Antitussive stemoninine alkaloids from the roots of Stemona tuberosa
Antitussive stemoninine alkaloids from the roots of Stemona tuberosa
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DOI：
10.1021/np070651
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发表时间：
2008-06-01
影响因子：
5.1
通讯作者：
Ye, Yang
中科院分区：
文献类型：
--
作者：
Lin, Li-Gen;Li, Kan Man;Ye, Yang
Investigation of the roots of Stemona tuberosa afforded five minor constituents, stemoenonine (1), 9a-0-methylstemoenonine (2), oxystemoenonine (3), 1,9a-seco-stemoenonine (4), and oxystemoninine (5), along with the known compound stemoninoamide (6). Their structures were elucidated by 1D and 2D NMR spectra and other spectroscopic studies. Alkaloids 1, 2, and 6, as well as the representative stemoninine-type alkaloid, stemoninine (7), were screened for antitussive activity in the citric acid-induced guinea pig cough model. Compounds 6 and 7 exhibited strong antitussive activity after oral and intraperitoneal administrations.
