MODULATION OF MECHANOSENSORY THRESHOLD IN APLYSIA BY SEROTONIN, SMALL CARDIOACTIVE PEPTIDE-B (SCPB), FMRFAMIDE, ACETYLCHOLINE, AND DOPAMINE
MODULATION OF MECHANOSENSORY THRESHOLD IN APLYSIA BY SEROTONIN, SMALL CARDIOACTIVE PEPTIDE-B (SCPB), FMRFAMIDE, ACETYLCHOLINE, AND DOPAMINE
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DOI：
10.1016/0304-3940(89)90037-2
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发表时间：
1989-10-23
影响因子：
2.5
通讯作者：
WALTERS, ET
中科院分区：
文献类型：
--
作者：
BILLY, AJ;WALTERS, ET
在给Auspsia的尾部注射已知会影响该动物防御行为的神经调节剂后，测试了该动物尾部感觉神经元的机械感觉阈值。5-羟色胺（5-HT）和小心脏活性肽（SPCB）降低外周阈值，而FMRFamide，乙酰胆碱（ACh）和多巴胺增加阈值。FMRFamide和ACh也减少感觉神经元的自发活动。谷氨酸和牛磺酸没有影响。SPCB效应在洗脱后持续15-30分钟。这些神经调质的外周和中枢效应之间的功能相似性支持这一假设的协调调制的两个区域的感觉神经元由同一组调制器伤害性刺激后。
Mechanosensory threshold of tail sensory neurons in Aplysia was tested after injecting the tail with neuromodulators known to affect defensive behavior in this animal. Serotonin (5-HT) and small cardioactive peptide (SPCB) reduced peripheral threshold, while FMRFamide, acetylcholine (ACh), and dopamine increased threshold. FMRFamide and ACh also reduced spontaneous activity of sensory neurons. Glutamate and taurine had no effect. SPCB effects persisted for 15-30 min after washout. Functional similarities between peripheral and central effects of these neuromodulators support the hypothesis of coordinate modulation of both regions of the sensory neuron by the same set of modulators following noxious stimulation.