Efficient synthesis of 5H-cyclopenta[c]quinoline derivatives via palladium-catalyzed domino reactions of o-alkynylhalobenzene with amine.
Efficient synthesis of 5H-cyclopenta[c]quinoline derivatives via palladium-catalyzed domino reactions of o-alkynylhalobenzene with amine.
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DOI：
10.1021/ol103173v
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发表时间：
2011-02
期刊：
影响因子：
5.2
通讯作者：
Yong Luo;Xiaolin Pan;Jie Wu
中科院分区：
文献类型：
--
作者：
Yong Luo;Xiaolin Pan;Jie Wu
报道了一种钯催化的邻炔卤代苯与胺的多米诺反应合成5 H-环戊二烯并[c]喹啉衍生物的新方法。该方法原料易得，反应过程平稳，反应效率高，反应范围广，官能团耐受性好。
A novel and efficient route for the synthesis of 5H-cyclopenta[c]quinoline derivatives via a palladium-catalyzed domino reaction of o-alkynylhalobenzene with amine is described. The starting materials are easily available, and the reaction proceeds smoothly with high efficiency, which shows broad scope with good functional group tolerance.