Dendritic Cells and Their Multiple Roles during Malaria Infection.
Dendritic Cells and Their Multiple Roles during Malaria Infection.
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DOI：
10.1155/2016/2926436
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发表时间：
2016
影响因子：
4.1
通讯作者：
Boscardin SB
中科院分区：
文献类型：
--
作者：
Amorim KN;Chagas DC;Sulczewski FB;Boscardin SB
树突状细胞（Dendritic cells，DC）在适应性免疫应答的启动中起重要作用，能有效地将抗原呈递给T细胞。这种能力依赖于许多表面和细胞内受体的存在，这些受体能够感知微生物组分以及炎症，并且依赖于非常有效的抗原呈递机制。以这种方式，DC感测到无数病原体的存在，包括疟原虫属，疟疾的病原体。尽管为控制这种感染作出了许多努力，但疟疾仍然是高发病率和死亡率的原因。不同的研究小组已经表明，DC在疟原虫感染期间起作用，并且数据表明表型不同的DC亚群是感染期间免疫调节的关键因素。在这篇综述中，我们将讨论的重要性，树突状细胞诱导免疫对不同阶段的疟原虫，树突状细胞激活的结果，以及目前已知的疟原虫成分，触发这种激活。
Dendritic cells (DCs) play a central role in the initiation of adaptive immune responses, efficiently presenting antigens to T cells. This ability relies on the presence of numerous surface and intracellular receptors capable of sensing microbial components as well as inflammation and on a very efficient machinery for antigen presentation. In this way, DCs sense the presence of a myriad of pathogens, including Plasmodium spp., the causative agent of malaria. Despite many efforts to control this infection, malaria is still responsible for high rates of morbidity and mortality. Different groups have shown that DCs act during Plasmodium infection, and data suggest that the phenotypically distinct DCs subsets are key factors in the regulation of immunity during infection. In this review, we will discuss the importance of DCs for the induction of immunity against the different stages of Plasmodium, the outcomes of DCs activation, and also what is currently known about Plasmodium components that trigger such activation.