CHANGES IN HEROIN SELF-ADMINISTRATION BY A RHESUS-MONKEY AFTER MORPHINE IMMUNIZATION
CHANGES IN HEROIN SELF-ADMINISTRATION BY A RHESUS-MONKEY AFTER MORPHINE IMMUNIZATION
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DOI：
10.1038/252708a0
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发表时间：
1974-01-01
期刊：
影响因子：
64.8
通讯作者：
SCHUSTER, CR
中科院分区：
文献类型：
--
作者：
BONESE, KF;WAINER, BH;SCHUSTER, CR
我们已经在一种灵长类动物身上研究了免疫抗阿片类药物对这些药物自我给药的影响。恒河猴会自我服用各种药物，包括阿片类药物和精神运动兴奋剂，我们利用恒河猴，观察了它们在注射吗啡免疫前后对海洛因的反应。结果表明，抗吗啡抗体可以阻断海洛因对中枢神经系统（CNS）维持自我给药行为的作用。
WE have investigated in one primate the effect of immunisation against an opiate on the self-administration of these drugs. Using the rhesus monkey, which will self-administer various drugs, including opiates and psychomotor stimulants1, we have followed the response for heroin before and after immunisation against morphine. Results indicate that antibodies against morphine can block those effects of heroin on the central nervous system (CNS) that maintain self-administration behaviour.