A new photothermal therapeutic agent:: Core-free nanostructured AuxAg1-x dendrites
A new photothermal therapeutic agent:: Core-free nanostructured AuxAg1-x dendrites
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DOI：
10.1002/chem.200800114
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发表时间：
2008-01-01
影响因子：
4.3
通讯作者：
Yeh, Chen-Sheng
中科院分区：
文献类型：
--
作者：
Hu, Kuo-Wei;Huang, Chih-Chia;Yeh, Chen-Sheng
利用Ag枝晶与HAuCl4水溶液之间的置换反应合成了一类具有枝晶形态和中空内部的新型AuxAg1-x纳米结构。 Ag纳米结构的枝晶是由AgNO3与抗坏血酸在甲醇/水系统中反应生成的。树突类似于珊瑚形状，由许多不对称排列的茎组成。每个茎的长度约为 400 nm，直径约为 65 nm。 AuxAg1-x 的双金属成分可以通过向银枝晶溶液中添加不同量的 HAuCl4 来调节。空心过程在 Au0.3Ag0.7 枝晶中形成壁厚为 10.5 nm 的管状结构。紫外/可见光谱表明，所得空心 AuxAg1-x 枝晶中最强的近红外吸收是在 Au0.3Ag0.7 中。采用MTT法评估Ag树突、空心Au0.06Ag0.94和Au0.3Ag0.7树突以及Au纳米棒的细胞毒性。结果发现，空心Au0.06Ag0.94和Au0.3Ag0.7树突表现出良好的生物相容性，而Ag树突和An纳米棒均表现出剂量依赖性毒性。由于在近红外区域的吸收，空心Au0.3Ag0.7树突被用作光热吸收剂来破坏A549肺癌细胞。将它们的光热性能与纳米棒光热治疗剂进行了比较。因此，相对于金纳米棒，空心 Au0.3Ag0.7 树突有效损伤癌细胞所需的粒子浓度和激光功率显着降低。空心 Au0.3Ag0.7 纳米结构树突显示出光热作用杀死癌细胞的潜力。
A new class of AuxAg1-x nanostructures with dendrite morphology and a hollow interior were synthesized by using a replacement reaction between Ag dendrites and an aqueous solution of HAuCl4. The Ag nanostructured dendrites were generated by the reaction of AgNO3 with ascorbic acid in a methanol/water system. The dendrites resemble a coral shape and are built up of many stems with an asymmetric arrangement. Each stem is approximately 400 nm in length and 65 nm in diameter. The bimetallic composition of AuxAg1-x can be tuned by the addition of different amounts of HAuCl4 to the Ag dendritic solution. The hollowing process resulted in tubular structures with a wall thickness of 10.5 nm in Au0.3Ag0.7 dendrites. The UV/Vis spectra indicate that the strongest NIR absorption among the resulting hollow AuxAg1-x dendrites was in Au0.3Ag0.7. The MTT assay was conducted to evaluate the cytotoxicity of Ag dendrites, hollow Au0.06Ag0.94 and Au0.3Ag0.7 dendrites, and Au nanorods. It was found that hollow Au0.06Ag0.94 and Au0.3Ag0.7 dendrites exhibited good biocompatibility, while both Ag dendrites and An nanorods showed dose-dependent toxicity. Because of absorption in the NIR region, hollow Au0.3Ag0.7 dendrites were used as photothermal absorbers for destroying A549 lung cancer cells. Their photothermal performance was compared to that of An nanorod photothermal therapeutic agents. As a result, the particle concentration and laser power required for efficient cancer cell damage were significantly reduced for hollow Au0.3Ag0.7 dendrites relative to those used for Au nanorods. The hollow Au0.3Ag0.7 nanostructured dendrites show potential in photothermolysis for killing cancer cells.