High Serum Irisin Level as an Independent Predictor of Diabetes Mellitus: A Longitudinal Population-Based Study.
High Serum Irisin Level as an Independent Predictor of Diabetes Mellitus: A Longitudinal Population-Based Study.
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DOI：
10.1097/md.0000000000003742
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发表时间：
2016-06
期刊：
影响因子：
1.6
通讯作者：
Chung CH
中科院分区：
文献类型：
--
作者：
Huh JH;Ahn SV;Choi JH;Koh SB;Chung CH
淫羊藿素是一种新型的运动诱导肌细胞因子，被认为可以调节能量稳态和胰岛素敏感性。然而，目前尚不清楚循环虹膜蛋白是否在人类糖尿病的发生发展中起作用。在一项长达2.6年的纵向研究中，我们调查了循环中虹膜蛋白水平与糖尿病发病之间的可能联系。这项研究以韩国农村受试者为研究对象，以人群为基础进行研究。2005年11月至2008年1月，我们在韩国基因组和流行病学研究(KoGES-Arirang)研究范围内进行了一项纵向研究，研究对象是韩国普通人群中农村地区的动脉粥样硬化风险。病例(n=85)是随访期间发生的糖尿病患者，对照组(n=85)根据基线时的性别和年龄与发生的糖尿病病例相匹配。采用条件Logistic回归分析血清淫羊藿素/脂联素水平对糖尿病发病的相对危险度。糖尿病患者的基线虹膜蛋白_ENREF_1水平显著高于非糖尿病患者。血清虹膜蛋白水平与糖化血红蛋白(HbA1c)和餐后血糖正相关。淫羊藿素与脂联素呈负相关(R=-0.189，P=0.014)。在调整了包括体重指数在内的潜在混杂因素后，发生糖尿病的优势比[95%可信区间]随着血清虹膜蛋白水平的增加而逐步增加(四分位1、四分位数2、四分位3、四分位4分别为1、0.80[0.28-2.35]、3.33[1.11-10.00]、4.10[1.35-12.44])，而发生糖尿病的优势比随着血清脂联素水平的增加而逐步降低。高水平的血清淫羊藿素与糖尿病的发生独立相关，提示在韩国成年人中，淫羊藿素可能是一个有用的预测糖尿病的指标。
Irisin, a novel exercise-induced myokine, has been suggested to regulate energy homeostasis and insulin sensitivity. However, it remains unclear whether circulating irisin plays a role in the development of DM in human. We investigated the possible association between circulating irisin levels and incident DM in a 2.6-year longitudinal study of a population-based cohort comprised of rural Korean subjects. We conducted a longitudinal study within the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population (KoGES-ARIRANG) study from November 2005 to January 2008. Cases (n=85) were patients with incident DM during the follow-up period and controls (n = 85) were matched to incident DM cases based on sex and age at baseline. The relative risk of serum irisin/adiponectin level for incident DM was analyzed using conditional logistic regression analysis. Baseline irisin_ENREF_1 levels were significantly higher in subjects who developed DM than in subjects who did not. The serum irisin level was positively associated with glycated hemoglobin (HbA1c) and postprandial glucose. Irisin was negatively associated with adiponectin (R = –0.189, P = 0.014). After adjustment for potential confounders, including body mass index, the odds ratios [95% confidence intervals] for incident DM increased in a graded manner as the serum irisin level increased (Quartile 1 vs Quartile 2 vs Quartile 3 vs Quartile 4 = 1 vs 0.80 [0.28–2.35] vs 3.33 [1.11–10.00] vs 4.10 [1.35–12.44], respectively), whereas the odds ratios for incident DM decreased in a graded manner as the serum adiponectin level increased. High serum irisin was independently associated with the development of DM, indicating that irisin may be a useful predictor of DM in Korean adults.