Inflammatory markers in cerebrospinal fluid: independent prognostic biomarkers in amyotrophic lateral sclerosis?
Inflammatory markers in cerebrospinal fluid: independent prognostic biomarkers in amyotrophic lateral sclerosis?
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DOI：
10.1136/jnnp-2018-319586
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发表时间：
2019-12-01
影响因子：
11
通讯作者：
Poesen, Koen
中科院分区：
文献类型：
--
作者：
Gille, Benjamin;De Schaepdryver, Maxim;Poesen, Koen
炎症是肌萎缩性侧索硬化症（ALS）的一个关键病理标志，似乎与疾病进展有关。目前尚不清楚ALS患者脑脊液（CSF）炎症标志物的附加诊断和预后价值。方法测定105例ALS患者（n=105）、102例对照患者（n=102）和16例模拟ALS患者（n=16）脑脊液和血清中几丁质三苷酶-1 （CHIT1）、几丁质酶-3样蛋白1 （YKL-40）和单核细胞趋化蛋白-1 （MCP-1）的含量。通过受试者工作特征曲线分析来评价其鉴别性能。脑脊液和血清水平与多个临床参数相关。多变量Cox回归分析，包括8个其他已建立的预后指标，用于评估ALS患者的生存。结果在脑脊液中，CHIT1、YKL-40和MCP-1对ALS和ALS模拟患者表现出较弱的区别表现(曲线下面积：0.79,p
Objective Inflammation is a key pathological hallmark in amyotrophic lateral sclerosis (ALS), which seems to be linked to the disease progression. It is not clear what the added diagnostic and prognostic value are of inflammatory markers in the cerebrospinal fluid (CSF) of patients with ALS.Methods Chitotriosidase-1 (CHIT1), chitinase-3-like protein 1 (YKL-40) and monocyte chemoattractant protein-1 (MCP-1) were measured in CSF and serum of patients with ALS (n=105), disease controls (n=102) and patients with a disease mimicking ALS (n=16). The discriminatory performance was evaluated by means of a receiver operating characteristic curve analysis. CSF and serum levels were correlated with several clinical parameters. A multivariate Cox regression analysis, including eight other established prognostic markers, was used to evaluate survival in ALS.Results In CSF, CHIT1, YKL-40 and MCP-1 showed a weak discriminatory performance between ALS and ALS mimics (area under the curve: 0.79, p