The pleiotropic roles of autophagy in Alzheimer's disease: From pathophysiology to therapy.
The pleiotropic roles of autophagy in Alzheimer's disease: From pathophysiology to therapy.
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DOI：
10.1016/j.coph.2021.07.011
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发表时间：
2021-10
影响因子：
4
通讯作者：
Rubinsztein DC
中科院分区：
文献类型：
--
作者：
Festa BP;Barbosa AD;Rob M;Rubinsztein DC
Autophagy is a lysosomal degradation pathway and the main clearance route of many toxic protein aggregates. The molecular pathology of Alzheimer's disease (AD) manifests in the form of protein aggregates—extracellular amyloid-β depositions and intracellular tau neurofibrillary tangles. Perturbations at different steps of the autophagy pathway observed in cellular and animal models of AD might contribute to amyloid-β and tau accumulation. Increased levels of autophagosomes detected in patients' brains suggest an alteration of autophagy in human disease. Autophagy is also involved in the fine-tuning of inflammation, which increases in the early stages of AD and possibly drives its pathogenesis. Mounting evidence of a causal link between impaired autophagy and AD pathology uncovers an exciting opportunity for the development of autophagy-based therapeutics.
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