Hybrid Vibrio vulnificus.
Hybrid Vibrio vulnificus.
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DOI：
10.3201/eid1101.040440
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发表时间：
2005-01
影响因子：
11.8
通讯作者：
Maiden MC
中科院分区：
文献类型：
--
作者：
Bisharat N;Cohen DI;Harding RM;Falush D;Crook DW;Peto T;Maiden MC
创伤弧菌自然种群之间的杂交导致了高侵入性克隆。利用多位点基因分型数据和现代分子进化分析工具，对以色列最近出现的人致病性创伤弧菌进行了调查。我们证明该病原菌是由两个不同和独立的种群的基因组杂交进化而来的杂交有机体。这些发现提供了清楚的证据，证明两种现有形式和非致病形式之间的杂交显然导致了由这种致病变异引起的流行传染病的出现。这一新颖的观察显示了流行生物体产生的另一种方式。
Hybridization between natural populations of Vibrio vulnificus results in hyperinvasive clone. The recent emergence of the human-pathogenic Vibrio vulnificus in Israel was investigated by using multilocus genotype data and modern molecular evolutionary analysis tools. We show that this pathogen is a hybrid organism that evolved by the hybridization of the genomes from 2 distinct and independent populations. These findings provide clear evidence of how hybridization between 2 existing and nonpathogenic forms has apparently led to the emergence of an epidemic infectious disease caused by this pathogenic variant. This novel observation shows yet another way in which epidemic organisms arise.