Role of Quercetin Benefits in Neurodegeneration
Role of Quercetin Benefits in Neurodegeneration
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DOI：
10.1007/978-3-319-28383-8_12
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Lakshmi, Sreeja
中科院分区：
文献类型：
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作者：
Elumalai, Preetham;Lakshmi, Sreeja
神经退行性疾病通常危及生命，并被雇佣为医疗保健系统的经济负担。采取了主要涉及多酚的营养干预措施，以阻止或扭转与年龄有关的健康障碍。黄酮类化合物是一类饮食多酚，由于其强大的抗氧化防御机制，在预防大脑疾病方面正成为超级明星。槲皮素是一种普遍存在的类黄酮，据报道，它具有多种纯天然的健康益处。除了一些草药如银杏外，柑橘类水果、苹果、洋葱、欧芹、浆果、绿茶和红酒是栎素的主要膳食补充剂。在降低神经退行性疾病、癌症、心血管疾病、过敏性疾病、血栓形成、动脉粥样硬化、高血压和心律失常等方面的可能性，归因于其高度显著的抗氧化和抗炎特性。神经退行性变的特征是神经元结构和功能的进行性恶化，关键是伴随着严重的认知缺陷。在阿尔茨海默病(AD)、帕金森病(PD)和亨廷顿病(HD)中，衰老是神经退行性疾病的主要危险因素。氧化应激和线粒体功能障碍是引发神经变性的关键因素。神经退行性疾病的激增总是令人震惊的，因为缺乏有效的治疗实践。过去几年的研究已经证实了槲皮素在许多方面有益于大脑健康的机制，包括改善认知输出。毫无疑问，无论是在科学研究方面，还是在药理和临床应用方面，槲皮素都将成为一个可耕种的领域。
Neurodegenerative disorders are often life threatening and hired as an economic burden to the health-care system. Nutritional interventions principally involving polyphenols were practiced to arrest or reverse the age-related health disorders. Flavonoids, a class of dietary polyphenols, are rising to superstardom in preventing brain disorders with their potent antioxidant defense mechanism. Quercetin is a ubiquitous flavonoid reported to have all-natural myriad of health benefits. Citrus fruits, apple, onion, parsley, berries, green tea, and red wine comprise the major dietary supplements of quercetin apart from some herbal remedies like Ginkgo biloba. Appositeness of quercetin in reducing risks of neurodegenerative disorders, cancer, cardiovascular diseases, allergic disorders, thrombosis, atherosclerosis, hypertension, and arrhythmia, to name a few, is attributed to its highly pronounced antioxidant and anti-inflammatory properties. Neurodegeneration, characterized by progressive deterioration of the structure and function of neurons, is crucially accompanied by severe cognitive deficits. Aging is the major risk factor for neurodegenerative disorders in Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) being coequal high hands. Oxidative stress and mitochondrial dysfunction are the key players in triggering neurodegeneration. The upsurge of neurodegenerative disorders is always appalling since there exists a paucity in effective treatment practices. Past few years' studies have underpinned the mechanisms through which quercetin boons the brain health in many aspects including betterment in cognitive output. Undoubtedly, quercetin will be escalating as an arable field, both in scientific research and in pharmacological and clinical applications.