Nax channel involved in CNS sodium-level sensing
Nax channel involved in CNS sodium-level sensing
复制标题
DOI：
10.1038/nn856
复制
发表时间：
2002-06-01
影响因子：
25
通讯作者：
Noda, M
中科院分区：
文献类型：
--
作者：
Hiyama, TY;Watanabe, E;Noda, M
当体液中水和钠之间的正确平衡被破坏时，哺乳动物会感到口渴或对盐有食欲，但人们对大脑中控制盐稳态的机制知之甚少。据推测，如果要涵盖实验数据，则渗透压感受器和特定钠受体的存在是必不可少的 1, 2。已鉴定出几种候选渗透压感受器 3,4,5，在这里我们表明，心室周围器官 (CVO) 中的 Na x 通道可能是特定钠受体的候选者。
Mammals feel thirsty or an appetite for salt when the correct balance between water and sodium in the body fluid has been disrupted, but little is known about the mechanism in the brain that controls salt homeostasis. It has been postulated that the existence of both an osmoreceptor and a specific sodium receptor is essential if the experimental data are to be encompassed 1, 2. Several candidate osmoreceptors have been identified 3, 4, 5, and here we show that the Na x channel in the circumventricular organs (CVO) is a probable candidate for the specific sodium receptor.