How Changes in Cell Mechanical Properties Induce Cancerous Behavior
How Changes in Cell Mechanical Properties Induce Cancerous Behavior
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DOI：
10.1103/physrevlett.108.028103
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发表时间：
2012-01-11
影响因子：
8.6
通讯作者：
Bonnecaze, Roger T.
中科院分区：
文献类型：
--
作者：
Katira, Parag;Zaman, Muhammad H.;Bonnecaze, Roger T.
肿瘤生长和转移最终是涉及细胞迁移和不受控制的分裂的机械过程。使用细胞的3D离散模型，我们表明，与周围的健康细胞相比，癌细胞观察到的顺应性增加导致它们以更快的速度生长。我们还显示了细胞间结合的变化如何影响肿瘤的恶性程度和转移潜力。这些发现表明，癌细胞机械特性的变化是不受控制的分裂和迁移的近因，各种生化因素通过这种机制驱动癌症进展。
Tumor growth and metastasis are ultimately mechanical processes involving cell migration and uncontrolled division. Using a 3D discrete model of cells, we show that increased compliance as observed for cancer cells causes them to grow at a much faster rate compared to surrounding healthy cells. We also show how changes in intercellular binding influence tumor malignancy and metastatic potential. These findings suggest that changes in the mechanical properties of cancer cells is the proximate cause of uncontrolled division and migration and various biochemical factors drive cancer progression via this mechanism.