Effects of induced thyroid deficiency on the development of suckling behavior in rats
Effects of induced thyroid deficiency on the development of suckling behavior in rats
复制标题
诱导性甲状腺缺乏症对大鼠哺乳行为发育的影响
DOI：
10.1016/0031-9384(82)90027-0
复制
发表时间：
1982
影响因子：
2.9
通讯作者：
R. Browne
中科院分区：
文献类型：
--
作者：
C. H. Narayanan;Y. Narayanan;R. Browne
The effects of propylthiouracil (PTU) on the ontogeny of suckling behavior in rats were examined. The drug was given at two dosage levels of 0.3% and 0.5% respectively mixed with rat diet throughout gestation and suckling. The thyroid glands of treated fetuses and pups and of untreated control animals of the same age groups were monitored by histologic examination. At the behavioral level, the frequency of individual movements of head, forelimbs and mouth was significantly reduced in treated fetuses. The combination movements of head, mouth and forelimbs showed severe deficits both quantitatively and qualitatively for all ages in the experimental group from day 18 of gestation. Hypothyroid pups of dams raised on 0.5% PTU were unable to attach to the nipple of the mother and died within a few days. Pups of dams raised on 0.3% PTU showed longer latencies for nipple attachment, and their gross motor movements of rooting and suckling were greatly impaired. These results have been discussed in relation to the development of suckling behavior to indicate that, during ontogeny, some decisive step in the integration of individual movements takes place in utero from day 18 of gestation. This coincides with the establishment of pituitary thyroid relationship, which is continued through postnatal stages.
