Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice
Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice
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DOI：
10.1038/ng2065
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发表时间：
2007-08-01
期刊：
影响因子：
30.8
通讯作者：
Hoog, Christer
中科院分区：
文献类型：
--
作者：
Kouznetsova, Anna;Lister, Lisa;Hoog, Christer
纺锤体组件检查点防止了染色体的错误分离，但不会在含有少数交叉染色体(单价体)的卵母细胞中引起停滞。在第一次减数分裂期间，我们跟踪了卵母细胞中单价体的命运，尽管这些单价体保留了减数分裂的动粒结构，但它们也是有丝分裂的双向的。单价体获得的杂交染色体构型使它们能够避开纺锤体组装检查点，从而促进卵母细胞的非整倍体。
The spindle assembly checkpoint guards against chromosomal missegregation but does not induce arrest in oocytes that contain a few achiasmatic chromosomes ( univalents). We followed the fate of univalents in oocytes during the first meiotic division, and although these preserved a meiotic kinetochore structure, they were also bi-oriented in a mitotic manner. The hybrid chromosomal configuration attained by univalents allows them to evade the spindle assembly checkpoint and contribute to aneuploidy in oocytes.