Enhancement of hemocompatibility on titanium implant with titanium-doped diamond-like carbon film evaluated by cellular reactions using bone marrow cell cultures in vitro
Enhancement of hemocompatibility on titanium implant with titanium-doped diamond-like carbon film evaluated by cellular reactions using bone marrow cell cultures in vitro
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DOI：
10.1116/1.3077271
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发表时间：
2009-05
影响因子：
1.4
通讯作者：
W. Feng;Chau-Hsiang Wang;H. Cheng;S. Chiou;C. Chen;K. Ou
中科院分区：
文献类型：
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作者：
W. Feng;Chau-Hsiang Wang;H. Cheng;S. Chiou;C. Chen;K. Ou
本研究的目的是评估一种新的方法来存款a-C：H薄膜与生物接受的钛作为一种保护涂层材料在生物医学应用。为此目的，通过组合的射频和磁控溅射系统将不同量的钛并入a-C：H膜中。为了了解含Ti和不含Ti的a-C：H薄膜的性能，通过材料分析和细胞培养对样品进行了评价。Ti和TiC嵌入并连接到非晶a-C：H基体中。a-C：H scinTi膜的成骨分化能力明显优于Ti和a-C：H，表明含Ti的a-C：H膜的生物相容性明显优于a-C：H膜。认为钛在提高膜的附着力和生物相容性方面起着重要作用。此外，它还揭示了血液相容性的问题，以及血液/a-C：H scinTi相互作用作为表面粗糙度的函数可以影响红细胞（RBC）在早期组织中的分布。
The purpose of this study is to evaluate a new method to deposit a-C:H film with the biological acceptance of titanium as a protective coating material in biomedical applications. For this purpose, various amounts of titanium were incorporated into a-C:H films by a combined radio frequency and magnetron sputtering system. In order to realize the properties of a-C:H films with and without Ti, the specimens were evaluated by material analyses and cell culture. The Ti and TiC were embedded in and connected to an amorphous a-C:H matrix. The a-C:H∕Ti film has better capability of osteoblast differentiation than Ti and a-C:H, revealing that the biocompatibility of a-C:H containing Ti is obviously better than a-C:H. It is believed that the Ti plays an important role in enhancing the film’s adhesion and biocompatibility. Furthermore, it also revealed the issue of hemocompatibility and that blood/a-C:H∕Ti interactions as a function of surface roughness can affect the red blood cell (RBC) distributions in early tis...