The influence of the human microbiome and probiotics on cardiovascular health.
The influence of the human microbiome and probiotics on cardiovascular health.
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DOI：
10.4161/19490976.2014.983775
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发表时间：
2014
期刊：
影响因子：
12.2
通讯作者：
Burton JP
中科院分区：
文献类型：
--
作者：
Ettinger G;MacDonald K;Reid G;Burton JP
心血管疾病（CVD）是全球范围内的主要死亡原因。在众多的致病因素中，微生物是其中之一。从肠道微生物群对能量代谢和肥胖的局部影响，到牙周病与冠心病的远端关联，微生物对心血管健康有显著影响。就调节或影响微生物的能力而言，已经考虑了益生菌应用。这些是活的微生物，当以足够的量给药时，其赋予宿主益处。虽然许多报告已经确定了某些益生菌菌株降低胆固醇和高血压的有益能力，但最近的研究表明，它们的使用可以更广泛地应用。本文综述了微生物组与CVD的已知关联以及益生菌治疗的潜在应用的最新总结。
Cardiovascular disease (CVD) is a major cause of death worldwide. Of the many etiological factors, microorganisms constitute one. From the local impact of the gut microbiota on energy metabolism and obesity, to the distal association of periodontal disease with coronary heart disease, microbes have a significant impact on cardiovascular health. In terms of the ability to modulate or influence the microbes, probiotic applications have been considered. These are live microorganisms which when administered in adequate amounts confer a benefit on the host. While a number of reports have established the beneficial abilities of certain probiotic bacterial strains to reduce cholesterol and hypertension, recent research suggests that their use could be more widely applied. This review presents an up-to-date summary of the known associations of the microbiome with CVD, and potential applications of probiotic therapy.