Untethered magnetic millirobot for targeted drug delivery
Untethered magnetic millirobot for targeted drug delivery
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DOI：
10.1007/s10544-015-9962-9
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发表时间：
2015-06-01
影响因子：
2.8
通讯作者：
Menciassi, Arianna
中科院分区：
文献类型：
--
作者：
Iacovacci, Veronica;Lucarini, Gioia;Menciassi, Arianna
本文报道了一种用于靶向治疗的新型毫米级机器人系统的设计和开发。所提出的医疗机器人被设想为在相对较小直径的身体管道（脊柱，泌尿系统，卵巢等）中进行治疗，并根据要治疗的病理释放几种治疗药物。该机器人是由嵌入治疗剂的载体和活塞组成的近浮力双组分系统。活塞利用磁效应与载体对接，压缩载药水凝胶，从而激活释放机制。利用外部磁场推动机器人向目标区域移动，同时利用磁力触发药物释放。在设计和制造机器人之后，该系统已经在载体中嵌入抗癌药物（阿霉素）进行了体外测试。药物释放机制的有效性已通过对药物释放量的量化和对该治疗程序对人类膀胱癌细胞的疗效评估得到证实。
This paper reports the design and development of a novel millimeter-sized robotic system for targeted therapy. The proposed medical robot is conceived to perform therapy in relatively small diameter body canals (spine, urinary system, ovary, etc.), and to release several kinds of therapeutics, depending on the pathology to be treated. The robot is a nearly-buoyant bi-component system consisting of a carrier, in which the therapeutic agent is embedded, and a piston. The piston, by exploiting magnetic effects, docks with the carrier and compresses a drug-loaded hydrogel, thus activating the release mechanism. External magnetic fields are exploited to propel the robot towards the target region, while intermagnetic forces are exploited to trigger drug release. After designing and fabricating the robot, the system has been tested in vitro with an anticancer drug (doxorubicin) embedded in the carrier. The efficiency of the drug release mechanism has been demonstrated by both quantifying the amount of drug released and by assessing the efficacy of this therapeutic procedure on human bladder cancer cells.