Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium
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DOI：
10.1002/alz.12033
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发表时间：
2020-01-01
影响因子：
14
通讯作者：
Wszolek, Zbigniew
中科院分区：
文献类型：
--
作者：
Miyagawa, Toji;Brushaber, Danielle;Wszolek, Zbigniew
前言：我们为CDR(R)PLUS NACC FTLD制定了全球评分规则，以发现和跟踪早期额颞叶变性(FTLD)并在FTLD中进行临床试验。方法：从额颞叶变性研究和治疗进展(ARTFL)/家族性额颞叶痴呆纵向评估(LEFFTDS)基线访问的970名散发性和家族性参与者应用CDR PLUS NACC FTLD评分。在确定全球得分时，CDR+NACC FTLD的八个领域中的每一个领域都被同等加权。结果：CDR+NACC FTLD具有很好的评分者间信度。讨论：CDR加NACC FTLD评分可作为有症状FTLD临床试验的一个有吸引力的结果指标，并可用于FTLD谱系障碍的自然病史研究和临床试验。
Introduction: We created global rating scoring rules for the CDR (R) plus NACC FTLD to detect and track early frontotemporal lobar degeneration (FTLD) and to conduct clinical trials in FTLD.Methods: The CDR plus NACC FTLD rating was applied to 970 sporadic and familial participants from the baseline visit of Advancing Research and Treatment in Frontotemporal Lobar Degeneration (ARTFL)/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS). Each of the eight domains of the CDR plus NACC FTLD was equally weighed in determining the global score. An interrater reliability study was completed for 40 participants.Results: The CDR plus NACC FTLD showed very good interrater reliability. It was especially useful in detecting clinical features of mild non-fluent/agrammatic variant primary progressive aphasia participants.Discussion: The global CDR plus NACC FTLD score could be an attractive outcome measure for clinical trials in symptomatic FTLD, and may be useful in natural history studies and clinical trials in FTLD spectrum disorders.