Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism.
Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism.
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DOI：
10.7150/ijbs.75488
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发表时间：
2022
影响因子：
9.2
通讯作者：
Shen, Linyuan
中科院分区：
文献类型：
--
作者：
Wang, Linghui;Qiu, Yanhao;Gu, Hao;Gan, Mailin;Zhu, Yan;Zhu, Kangping;Chen, Lei;Zhao, Ye;Niu, Lili;Zhang, Shunhua;Li, Xuewei;Zhu, Li;Shen, Linyuan
脂肪组织的功能受到遗传学、表观遗传学和环境之间复杂相互作用的影响，其功能障碍可导致多种代谢疾病，例如肥胖或2型糖尿病（T2D）。米色/棕色脂肪组织通过增加能量代谢产生热量，在调节葡萄糖和脂质代谢中发挥着至关重要的作用。脂肪组织生热程序是一个复杂的网络，涉及许多由编码转录因子的编码 RNA (cRNA) 和非编码 RNA (ncRNA)（包括 microRNA (miRNA) 和长非编码 RNA (lncRNA)）调节的信号通路。本文讨论了调节脂肪组织产热的因素，包括 cRNA 和 ncRNA，以及产热脂肪组织在肥胖相关代谢综合征中的重要作用。多项研究表明，一些 cRNA 和 ncRNA 可以以不同的方式调节脂肪组织的生热功能。本文综述了cRNA和ncRNA在调节米色/棕色脂肪组织生热作用中的作用以及米色/棕色脂肪组织在维持体内糖脂代谢平衡中的重要作用。
The function of the adipose tissue is influenced by complex interactions between genetics, epigenetics, and the environment, and its dysfunction can cause a variety of metabolic diseases, such as obesity or type 2 diabetes (T2D). The beige/brown adipose tissue plays a crucial role in regulating glucose and lipid metabolism by increasing energy metabolism to generate heat. The adipose tissue thermogenic program is a complex network that involves many signaling pathways regulated by coding RNAs (cRNAs) that encode transcription factor, and non-coding RNAs (ncRNAs) including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). This article discusses factors that regulate adipose tissue thermogenesis, including cRNAs and ncRNAs, and the important role of thermogenic adipose tissue in obesity-related metabolic syndrome. Several studies have shown that some cRNAs and ncRNAs can modulate the thermogenic function of adipose tissue in different ways. This article reviews the roles of cRNAs and ncRNAs in regulating thermogenesis in the beige/brown adipose tissue and the important role of the beige/brown adipose tissue in maintaining the balance of glucose and lipid metabolism in the body.
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影响因子：
3.6
作者：
Fa H;Xiao D;Chang W;Ding L;Yang L;Wang Y;Wang M;Wang J
通讯作者：
Wang J
影响因子：
29
作者：
Altshuler-Keylin S;Shinoda K;Hasegawa Y;Ikeda K;Hong H;Kang Q;Yang Y;Perera RM;Debnath J;Kajimura S
通讯作者：
Kajimura S
mRNA 和 lncRNA 表达谱的综合分析表明它们对衰老引起的棕色脂肪功能障碍的潜在贡献
影响因子：
5.2
作者：
Feng, Jie;Xu, Haoqin;Cui, Xianwei
通讯作者：
Cui, Xianwei
影响因子：
16.6
作者：
Berry DC;Jiang Y;Graff JM
通讯作者：
Graff JM
影响因子：
16.6
作者：
Ding C;Lim YC;Chia SY;Walet ACE;Xu S;Lo KA;Zhao Y;Zhu D;Shan Z;Chen Q;Leow MK;Xu D;Sun L
通讯作者：
Sun L