A common vaccination strategy to solve unsolved problems of tuberculosis and pertussis?
A common vaccination strategy to solve unsolved problems of tuberculosis and pertussis?
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DOI：
10.1016/j.micinf.2008.07.008
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发表时间：
2008-07-01
影响因子：
5.8
通讯作者：
Locht, Camille
中科院分区：
文献类型：
--
作者：
Locht, Camille
呼吸道病原体是世界上最成功的杀手之一。结核病每年造成约200万人死亡，百日咳每年造成约30万人死亡。尽管这两种疾病在其发病机制的表达和其病原体的生物学方面存在根本性差异，但提出了一种共同的异源初免/加强疫苗接种策略，使用针对结核病的减毒活疫苗（已经存在的BCG）和百日咳（一种新的减毒百日咳博德特氏菌菌株）在生命早期进行初免，然后用无细胞疫苗加强，基于用于结核病的新型肝素结合血凝素，以及已有的用于百日咳的无细胞疫苗。(C)2008年，Elsevier Masson SAS。All rights reserved.
Respiratory pathogens are amongst the world's most successful killers. Tuberculosis kills approximately 2 million individuals each year, and pertussis is responsible for roughly 300,000 annual deaths. Although the two diseases are fundamentally different in the expression of their pathogenesis and in the biology of their causative agents, a common heterologous prime/boost vaccination strategy is proposed, using live attenuated vaccines against tuberculosis (the already existing BCG) and pertussis (a novel attenuated Bordetella pertussis strain) early in life for priming, followed by a booster with acellular vaccines, based on the novel heparin-binding haemagglutinin for tuberculosis, and already available acellular vaccines against pertussis. (C) 2008 Elsevier Masson SAS. All rights reserved.