Suberitane sesterterpenoids from the Antarctic sponge Phorbas areolatus (Thiele, 1905)
Suberitane sesterterpenoids from the Antarctic sponge Phorbas areolatus (Thiele, 1905)
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DOI：
10.1016/j.tetlet.2018.07.055
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发表时间：
2018-09-05
影响因子：
1.8
通讯作者：
Thomas, Olivier P.
中科院分区：
文献类型：
--
作者：
Solanki, Hiren;Angulo-Preckler, Carlos;Thomas, Olivier P.
在进行生态和化学筛选后，首次对南极海绵Phorbas areolatus进行了化学研究。通过核磁共振分析，鉴定了3个新的辛二烯衍生物，分别命名为异辛二烯酮B、19-表辛二烯酮B和异氧杂螺辛二烯酮，以及已知的辛二烯酮A和B和氧杂螺辛二烯酮。发现这些化合物表现出中等的细胞毒性活性，并且它们在该海绵中的存在排除了它们作为Suberites海绵的化学分类学标记的用途。(C)2018爱思唯尔有限公司版权所有。
Following ecological and chemical screenings, the Antarctic sponge Phorbas areolatus was chemically investigated for the first time. Three new suberitane derivatives named isosuberitenone B, 19-episuberitenone B, and isoxaspirosuberitenone were identified together with the known compounds suberitenones A and B, and oxaspirosuberitenone after a thorough inspection of their NMR data. These compounds were found to exhibit moderate cytotoxic activity and their presence in this sponge rules out their use as a chemotaxonomic marker for Suberites sponges. (C) 2018 Elsevier Ltd. All rights reserved.