METABOLIC CONSEQUENCES OF EXPOSURE TO POLYCHLORINATED-BIPHENYLS (PCB) IN SEWAGE-SLUDGE
METABOLIC CONSEQUENCES OF EXPOSURE TO POLYCHLORINATED-BIPHENYLS (PCB) IN SEWAGE-SLUDGE
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DOI：
10.1093/oxfordjournals.aje.a113024
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发表时间：
1980-01-01
影响因子：
5
通讯作者：
NEEDHAM, LL
中科院分区：
文献类型：
--
作者：
BAKER, EL;LANDRIGAN, PJ;NEEDHAM, LL
在印第安纳州布卢明顿[美国]用作肥料的污水污泥中发现了多氯联苯。多氯联苯被一家电容器制造厂排入城市污水系统。为了研究多氯联苯暴露的流行病学和代谢后果，进行了流行病学和临床调查。89名污泥使用者的平均血清PCB水平为17.4 ppb，18名职业接触PCB的工人为75.1 ppb，19名工人家庭成员为33.6 ppb，22名社区居民为24.4 ppb。在污泥用户中，PCB水平与花园护理的百分比表现呈正相关（P = 0.035），与园艺时戴手套呈负相关（P = 0.021），但与使用的污泥量或暴露时间无显着相关。没有一组出现氯痤疮或多氯联苯中毒的全身症状。未发现PCB水平与血液学、肝或肾功能测试之间存在显著相关性。饮酒组和不饮酒组血浆甘油三酯水平均随PCB浓度的升高而显著升高（r = 0.541，n = 36，P < 0.001）。多氯联苯在接触和生物累积不足以产生明显症状的水平上可能改变脂质代谢。
Polychlorinated biphenyls (PCB) were discovered in sewage sludge used for fertilizer in Bloomington, Indiana [USA]. PCB were discharged into the municipal sewage system by an electrical capacitor manufacturing plant. To study epidemiology and metabolic consequences of PCB exposure, an epidemiologic and clinical survey was conducted. Mean serum PCB levels were 17.4 ppb in 89 sludge users, 75.1 ppb in 18 workers with occupational exposure to PCB, 33.6 ppb in 19 members of those workers'' families and 24.4 ppb in 22 community residents without unusual exposure to PCB. In sludge users, PCB levels were positively associated with percent performance of garden care (P = 0.035) and negatively with wearing gloves while gardening (P = 0.021) but were not significantly associated with amount of sludge used or duration of exposure. In no groups were chloracne or systemic symptoms of PCB toxicity noted. No significant correlations were found between PCB levels and tests of hematologic, hepatic or renal function. Plasma triglyceride levels increased significantly with serum PCB concentrations in alcohol drinkers and nondrinkers (r = 0.541, n = 36, P < 0.001 for nondrinkers). PCB may alter lipid metabolism at levels of exposure and bioaccumulation insufficient to produce overt symptoms.