Cationic facially amphiphilic poly(phenylene ethynylene)s studied at the air-water interface
Cationic facially amphiphilic poly(phenylene ethynylene)s studied at the air-water interface
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DOI：
10.1021/la0268597
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发表时间：
2003-03-18
期刊：
影响因子：
3.9
通讯作者：
Tew, GN
中科院分区：
文献类型：
--
作者：
Arnt, L;Tew, GN
设计在功能和结构上模仿天然生物聚合物的二级构象和化学丰富的聚合物是一个重要的目标。基于间亚苯基乙炔基的聚合物沿着主链用极性、阳离子和非极性烷基进行图案化，并具有类似于两亲性β-折叠肽的重复。这些聚合物通过 Langmuir 技术在空气-水界面进行了表征，发现它们采用边缘、两亲、延伸的构象，每个重复单元的面积类似于 42 埃。正如磷脂囊泡裂解实验所示，它们也具有膜活性。
The design of secondary conformation and chemically rich polymers that mimic natural biopolymers in function and structure is an important goal. Polymers based on meta-phenylene ethynylenes were patterned with polar, cationic, and nonpolar alkyl groups along the backbone with a repeat similar to amphiphilic beta-sheet peptides. These polymers were characterized at the air-water interface by Langmuir techniques and found to adopt an edge-on, amphiphilic, extended conformation with an area per repeat unit of similar to42 Angstrom. They are also membrane active as shown by phospholipid vesicle lysis experiments.