Early Lung Adenocarcinoma in Mice: Micro-Computed Tomography Manifestations and Correlation with Pathology.
Early Lung Adenocarcinoma in Mice: Micro-Computed Tomography Manifestations and Correlation with Pathology.
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DOI：
10.1016/j.tranon.2017.02.003
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发表时间：
2017-06
影响因子：
5
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Deng L;Xiao SM;Qiang JW;Li YA;Zhang Y
肺癌是男性和女性最常见的致命恶性肿瘤，腺癌是最常见的组织学类型。肺癌的早期诊断可以显着提高患者的生存率。本研究旨在探讨小鼠早期肺腺癌（LAC）的显微计算机断层扫描（micro-CT）表现，为早期临床诊断提供新视角。通过皮下注射1-甲基-3-硝基-1-亚硝基胍（MNNG）溶液建立10只小鼠的早期LAC模型。对小鼠肺部进行显微 CT 扫描和多平面重建 (MPR)。分析早期 LAC 的显微 CT 特征，特别是肿瘤与支气管的关系，并与病理学相关联。早期LAC的显微CT表现分为三种类型：非实性（n = 8, 6%）、部分实性（n = 85, 64%）和完全实性（n = 39, 30%）。 132例（83%）LAC中的110例可观察到肿瘤-支气管关系，分为四种类型：I型（n = 16，15%），支气管在肿瘤边缘截断； II型（n = 33, 30%），支气管侵入肿瘤，并逐渐变窄和中断； III型（n = 38，35%），支气管侵入肿瘤，管腔开放且完整； IV 型（n = 99, 90%），支气管位于肿瘤边界，管腔完整或受压。早期 LAC 的显微 CT 表现与病理结果密切相关。 Micro-CT可以清楚地展示小鼠早期LAC的特征以及支气管与肿瘤的关系，也可以为早期LAC的研究提供新的工具和视角。
Lung cancer is the most common fatal malignancy for both men and women and adenocarcinoma is the most common histologic type. Early diagnosis of lung cancer can significantly improve the survival rate of patients. This study aimed to investigate the micro-computed tomography (micro-CT) manifestations of early lung adenocarcinoma (LAC) in mice and to provide a new perspective for early clinical diagnosis. Early LAC models in 10 mice were established by subcutaneously injecting 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) solution. Micro-CT scan and multiple planar reconstruction (MPR) were used for mouse lungs. Micro-CT features of early LAC, especially the relationships between tumor and bronchus, were analyzed and correlated with pathology. Micro-CT findings of early LAC were divided into three types: non-solid (n = 8, 6%), partly solid (n = 85, 64%) and totally solid (n = 39, 30%). Tumor-bronchus relationships, which could be observed in 110 of 132(83%) LAC, were classified into four patterns: type I (n = 16, 15%), bronchus was truncated at the margin of the tumor; type II (n = 33, 30%), bronchus penetrated into the tumor with tapered narrowing and interruption; type III (n = 38, 35%), bronchus penetrated into the tumor with a patent and intact lumen; type IV (n = 99, 90%), bronchus ran at the border of the tumor with an intact or compressed lumen. Micro-CT manifestations of early LAC correlated well with pathological findings. Micro-CT can clearly demonstrate the features of mouse early LAC and bronchus-tumor relationships, and can also provide a new tool and perspective for the study of early LAC.