Adolescent girls with polycystic ovary syndrome showing different phenotypes have a different metabolic profile associated with increasing androgen levels
Adolescent girls with polycystic ovary syndrome showing different phenotypes have a different metabolic profile associated with increasing androgen levels
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DOI：
10.1016/j.fertnstert.2008.06.004
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发表时间：
2009-08-01
影响因子：
6.7
通讯作者：
Genazzani, Andandrea R.
中科院分区：
文献类型：
--
作者：
Fruzzetti, Franca;Perini, Daria;Genazzani, Andandrea R.
目的：探讨不同表型青少年多囊卵巢综合征（PCOS）的代谢特征。设计：观察性研究。地点：大学门诊。患者：120例PCOS青少年患者分为四组：少经多毛（O-H, n = 50）、少经多毛、多囊卵巢（PCO-O-H, n = 22）、少经多毛、高雄激素血症（A-O-H, n = 28）、少经多毛、高雄激素血症、多囊卵巢（PCO-A-O-H, n = 20）。对照组为年龄匹配的青少年（n = 30）。干预措施：受试者接受物理和超声评估；取空腹血，测定内分泌和代谢参数。主要观察指标：评估内分泌和代谢状况。结果：多囊卵巢综合征青少年患者胰岛素敏感性降低，血脂异常。甘油三酯、总胆固醇和低密度脂蛋白胆固醇在高雄激素血症表型中较高。胰岛素抵抗和体重指数在PCOS表型间无显著差异。甘油三酯和高密度脂蛋白胆固醇水平与游离睾酮和游离雄激素指数呈正相关。结论：不同表型的青春期PCOS患者发生代谢改变的风险可能存在差异。高雄激素血症是血脂异常的危险因素。这一信息可能与咨询多囊症青少年有关。[j] .中国农业科学（英文版），2009;32(2):626- 634。(C)2009年美国生殖医学学会。)
Objective: To evaluate the metabolic profiles of adolescents with different phenotypes of polycystic ovary syndrome (PCOS).Design: Observational study.Setting: University outpatient clinic.Patient(s): Adolescents with PCOS (n = 120) were divided into four groups: oligomenorrhea and hirsutism (O-H, n = 50), oligomenorrhea, hirsutism, and polycystic ovaries (PCO-O-H, n = 22), oligomenorrhea, hirsutism, and hyperandrogenemia (A-O-H, n = 28), oligomenorrhea, and hirsutism, hyperandrogenemia, and polycystic ovaries (PCO-A-O-H, n = 20). A control group of age-matched adolescents (n = 30) was included.Intervention(s): Subjects underwent physical and ultrasound evaluations; fasting blood samples were taken for the measurement of endocrine and metabolic parameters.Main Outcome Measure(s): The endocrine and metabolic profiles were evaluated.Result(s): Adolescents with PCOS showed reduced insulin sensitivity and dyslipidemia. Triglycerides, and total and low-density lipoprotein cholesterol were higher in the phenotypes with hyperandrogenemia. Insulin resistance and body mass index were not significantly different between PCOS phenotypes. Triglyceride positively and high-density lipoportein cholesterol levels negatively correlated with free testosterone and free androgen index.Conclusion(s): The risk of metabolic alterations may vary in adolescent PCOS patients with different phenotypes. Hyperandrogenemia is a risk factor for dyslipidemia. This information may be of relevance in counseling adolescents with PCOS. (Fertil Steril (R) 2009;92:626-34. (C)2009 by American Society for Reproductive Medicine.)