An outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates, 1994-1995
An outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates, 1994-1995
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DOI：
10.4269/ajtmh.1997.57.519
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发表时间：
1997-11-01
影响因子：
3.3
通讯作者：
Ksiazek, TG
中科院分区：
文献类型：
--
作者：
Khan, AS;Maupin, GO;Ksiazek, TG
在阿拉伯联合酋长国进行了多方面的调查，以确定1994年11月在屠宰场工人中发现的克里米亚-刚果出血热(CCHF)暴发的流行病学和生态因素。对1994年1月至1995年3月发病的病毒性出血热住院疑似病例进行了病历回顾，并用酶联免疫吸附试验对现有标本进行了病毒抗原、免疫球蛋白G和免疫球蛋白M抗体的血清学检测。对家畜饲养员和动物皮肤加工者进行了访谈和检测，以了解是否存在免疫球蛋白抗体。对进口和国产反刍动物的血清进行了CCHF病毒抗体检测，并用抗原捕获酶联免疫吸附试验(EL ISA)检测了从这些动物采集的硬蜱。已确认35例CCHF疑似病例(病死率=62%)。在28例已知职业状态的病例中，畜牧市场从业人员、屠宰场工人和动物皮肤加工者占16例(57%)。291只家畜和屠宰场工人中有12人(4%)有既往无症状感染的血清学证据，但没有一名对照组有此证据。在268头动物中，有19头(7%)的CCHF病毒抗体阳性，其中包括12头来自索马里和伊朗的反刍动物和5头本地骆驼。1例来自索马里牛的透明线虫和2例来自索马里牛的漏斗透明线虫和1例来自索马里山羊的透明线虫对CCHF病毒抗原呈阳性反应。
A multi-faceted investigation was conducted in the United Arab Emirates to characterize the epidemiologic and ecologic factors underlying an outbreak of Crimean-Congo hemorrhagic fever (CCHF) noted in November 1994 among abattoir workers. A chart review was conducted among hospitalized suspected cases of viral hemorrhagic fever with onset between January 1994 and March 1995 coupled with serologic testing of available specimens for the presence of virus antigen and IgG and IgM antibodies by ELISA. Livestock handlers and animal skin processors were interviewed and tested for the presence of IgG antibody. Sera from imported and domestic ruminants were examined for antibody for CCHF virus, and ticks collected from these animals were tested with an antigen-capture ELISA. Thirty-five suspected cases of CCHF were identified (case fatality = 62%). Livestock market employees, abattoir workers, and animal skin processors accounted for 16 (57%) of 28 cases with known occupational status. Serologic evidence of past asymptomatic infection was noted in 12 (4%) of 291 livestock and abattoir workers but in none of the controls. Nineteen (7%) of 268 animals were positive for CCHF virus antibodies by ELISA including 12 ruminants from Somalia and Iran and five indigenous camels. One Hyalomma impeltatum and two H. excavatum from Somali cattle and one H. anatolicum from a Somali goat were positive for CCHF virus antigen.