Allocryptopine: A Review of Its Properties and Mechanism of Antiarrhythmic Effect
Allocryptopine: A Review of Its Properties and Mechanism of Antiarrhythmic Effect
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别隐托品：其抗心律失常作用的性质和机制的综述
DOI：
10.2174/1389203720666190807123609
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发表时间：
2019
影响因子：
2.8
通讯作者：
Yang Li
中科院分区：
文献类型：
--
作者：
Jie Li;Bin Li;Hailiang Huang;Tao Han;Yang Li
Throughout the last decade, extensive efforts have been devoted to developing a percutaneous catheter ablation and implantable cardioverter-defibrillator technique for patients suffering from ventricu lar arrhythmia. Antiarrhythmic drug efficacy for preventing arrhythmias remains disappointing because of adverse cardiovascular effects. Allocryptopine is an isoquinoline alkaloid widely present in medicinal herbs. Studies have indicated that allocryptopine exhibits potential anti-arrhythmic actions in various animal models. The potential therapeutic benefit of allocryptopine in arrhythmia diseases is addressed in this study, focusing on multiple ion channel targets and reduced repolarization dispersion. The limitations of allocryptopine research are clear given a lack of parameters regarding toxicology and pharmacokinet ics and clinical efficacy in patients with ventricular arrhythmias. Much remains to be revealed about the properties of allocryptopine.
