Reaction of the antithrombotic and antimetastatic agent, nafazatrom, with oxidizing radicals.
Reaction of the antithrombotic and antimetastatic agent, nafazatrom, with oxidizing radicals.
复制标题
抗血栓和抗转移剂 nafazatrom 与氧化自由基的反应。
DOI：
10.1016/s0006-291x(83)80005-9
复制
发表时间：
1983
影响因子：
3.1
通讯作者：
Marnett,LJ
中科院分区：
文献类型：
--
作者：
Sevilla,MD;Neta,P;Marnett,LJ
抗血栓和抗转移药物萘扎特龙的脉冲辐解和电子自旋共振实验已经完成。结果表明，萘扎特龙是一个非常活跃的自由基清除剂。它与Br2−的反应速率高于生物重要的抗氧化剂生育酚和抗坏血酸盐的反应速率。ESR表明萘唑草酮氧化形成的自由基具有类似于苯氧基自由基的结构。发现这种自由基以接近扩散控制速率的速率衰减。萘扎曲姆的易氧化性使其非常适合作为抗氧化剂。这种性质可能是其药理活性的重要决定因素。
Pulse radiolysis and electron spin resonance experiments have been performed on the antithrombotic and antimetastatic agent, nafazatrom. Results show that nafazatrom is an extremely reactive scavenger of free radicals. The rate of its reaction with Br2−is higher than rates found for biologically important antioxidants, tocopherol and ascorbate. The radical formed by oxidation of nafazatrom is indicated by ESR to have a structure similar to phenoxyl radical. This radical is found to decay at a rate approaching diffusion controlled rates. The ease of oxidation of nafazatrom makes it ideally suited to act as an antioxidant. This property may be an important determinant of its pharmacological activities.