CORONARY HEART-DISEASE, CANCER AND MORTALITY IN MALE MIDDLE-AGED LIGHT SMOKERS
CORONARY HEART-DISEASE, CANCER AND MORTALITY IN MALE MIDDLE-AGED LIGHT SMOKERS
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DOI：
10.1111/j.1365-2796.1992.tb00944.x
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发表时间：
1992-04-01
影响因子：
11.1
通讯作者：
WEDEL, H
中科院分区：
文献类型：
--
作者：
ROSENGREN, A;WILHELMSEN, L;WEDEL, H
我们研究了轻度吸烟与冠心病（CHD）发病率的关系，样本包括6879名年龄在47- 55岁之间的男性，基线时无心肌梗死（MI）病史。在平均随访11.8年后，11.0%的每天吸烟1-4支的男性（n = 228）发生了重大冠心病事件，而非吸烟者（n = 2049）为3.7%[调整后的比值比为2.8（1.7-4.7）]。在吸烟更多的男性中没有观察到风险进一步增加。每天吸烟的数量越多，死于癌症的风险越大。所有类别的吸烟者的死亡率均增加，特别是重度吸烟者，其死亡风险为22%，而非吸烟者的死亡风险为6%[调整后的比值比为4.4（2.7-7.1）]。4年后的一项检查数据只考虑了那些在两种情况下吸烟习惯相同的男性（n = 3981）。在这些受试者中，平均7.1年后，每天吸烟1-4支的男性CHD发病率为10.6%，而非吸烟者为2.6%[校正的O.R. 4.6（2.1-10.1）]。未观察到剂量反应效应。即使是非常轻的吸烟也会大大增加中年男性患冠心病的风险。
We examined the effect of light smoking in relation to incidence of coronary heart disease (CHD) in a general population sample consisting of 6879 men aged 47- 55 years and free of previous myocardial infarction (MI) at baseline. After a follow-up of mean duration 11.8 years, 11.0 % of men smoking 1-4 cigarettes daily (n = 228) had suffered a major CHD event, compared to 3.7% of non-smokers (n = 2049) [adjusted odds ratio 2.8 (1.7-4.7)]. No further increase in risk was observed in men who smoked more. There was an increasing risk of death from cancer with the number of cigarettes smoked per day. Mortality was increased in all categories of cigarette smokers, particularly among the very heavy smokers, who had a mortality risk of 22% compared to 6% among non-smokers [adjusted odds ratio 4.4 (2.7-7.1)]. Data from an examination 4 years later considered only those men who stated that their smoking habits were identical on both occasions (n = 3981). Among these subjects the incidence of CHD after a mean period of 7.1 years was 10.6 % in men smoking 1-4 cigarettes per day, compared to 2.6 % in non-smokers [adjusted O.R. 4.6 (2.1-10.1)]. No dose-response effect was observed. Even very light cigarette smoking considerably increases the risk of CHD in middle-aged men.