Association Study of PDE48 Gene Variants in Scandinavian Schizophrenia and Bipolar Disorder Multicenter Case-Control Samples
Association Study of PDE48 Gene Variants in Scandinavian Schizophrenia and Bipolar Disorder Multicenter Case-Control Samples
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DOI：
10.1002/ajmg.b.30958
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发表时间：
2010-01-01
影响因子：
2.8
通讯作者：
Djurovic, Srdjan
中科院分区：
文献类型：
--
作者：
Kahler, Anna K.;Otnaess, Mona K.;Djurovic, Srdjan
磷酸二酯酶4B（PDE4B）是精神分裂症（SZ）和双相情感障碍（BP）的候选易感基因，在动物模型中参与认知功能。PDE4B的变异以前与SZ相关，具有性别特异性效应。我们分别对来自斯堪的纳维亚精神病病因学协作组（SCOPE）的SZ和BP多中心样本中的40个和72个标记单核苷酸多态性（tagSNPs）进行了基因分型和分析，涉及837例SZ病例和1，473例对照，加上594例BP病例和1，421例部分重叠对照。6个和16个tagSNPs名义上相关（0.0005
The phosphodiesterase 4B (PDE4B), which is involved in cognitive function in animal models, is a candidate susceptibility gene for schizophrenia (SZ) and bipolar disorder (BP). Variations in PDE4B have previously been associated with SZ, with a suggested gender-specific effect. We have genotyped and analyzed 40 and 72 tagging single nucleotide polymorphisms (tagSNPs) in SZ and BP multicenter samples, respectively, from the Scandinavian Collaboration on Psychiatric Etiology (SCOPE), involving 837 SZ cases and 1,473 controls plus 594 BP cases and 1,421 partly overlapping controls. Six and 16 tagSNPs were nominally associated (0.0005