Arterial stiffness, carotid artery intima-media thickness and plasma myeloperoxidase level in children with type 1 diabetes
Arterial stiffness, carotid artery intima-media thickness and plasma myeloperoxidase level in children with type 1 diabetes
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DOI：
10.1016/j.diabres.2009.01.014
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发表时间：
2009-05-01
影响因子：
5.1
通讯作者：
Tillmann, Vallo
中科院分区：
文献类型：
--
作者：
Heilman, Kaire;Zilmer, Mihkel;Tillmann, Vallo
目的：本研究采用新的动脉粥样硬化生化标志物--血浆髓过氧化物酶水平，探讨了1型糖尿病（T1 DM）患儿动脉沿着的功能-结构变化。我们研究了30名年龄为4.7-18.6岁的T1 DM儿童（平均T1 DM病程5.4 ± 3.4年，平均HbA（1C）9.8%）和30例健康受试者，按性别、年龄和体重指数匹配。采集空腹血样进行髓过氧化物酶（MPO）检测。超声和脉搏波分析用于测量颈动脉内膜中层厚度（IMT）、校正至心率75的增强指数（AIx@75）和脉搏波速度（PWV）。糖尿病患儿血浆MPO水平显著高于对照组，（p = 0.006），与对照组相比，AIx@75（p = 0.02）、IMT（p = 0.005）和IMT标准差评分（IMT SDS）（p = 0.02）增加。IMT SDS与HbA（1C）呈正相关（T = 0.39，p = 0.05）。PWV，调整年龄和平均动脉血压，与糖尿病病程（r = 0.49，p = 0.02）。结论：儿童T1 DM有显着升高的血浆髓过氧化物酶水平以及动脉粥样硬化相关的结构和功能的变化的动脉壁。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Objective: The present study investigated the functional-structural changes of the arteries along with a new biochemical marker of atherosclerosis, plasma myeloperoxidase level, in children with type 1 diabetes (T1DM).Methods: We studied 30 children with T1DM, aged 4.7-18.6 years (mean T1DM duration 5.4 +/- 3.4 years, mean HbA(1C) 9.8%) and 30 healthy subjects, matched by sex, age and body mass index. Fasting blood samples were obtained for myeloperoxidase (MPO). Ultrasonography and pulse wave analysis were used to measure carotid intima-media thickness (IMT), augmentation index corrected to a heart rate of 75 (AIx@75) and pulse wave velocity (PWV).Results: Children with diabetes had significantly higher plasma MPO levels (p = 0.006), increased AIx@75 (p = 0.02), IMT (p = 0.005) and IMT standard deviation scores (IMT SDS) (p = 0.02), compared to the control group. IMT SDS correlated positively with HbA(1C) (T = 0.39, p = 0.05). PWV, adjusted for age and mean arterial blood pressure, correlated with diabetes duration (r = 0.49, p = 0.02).Conclusions: Children with T1DM have substantially elevated plasma levels of myeloperoxidase as well as atherosclerosis-related structural and functional changes of the arterial wall. (C) 2009 Elsevier Ireland Ltd. All rights reserved.