SYNTHESIS, CHARACTERIZATION, AND POLYMERIZATION OF GLYCIDYL METHACRYLATE DERIVATIZED DEXTRAN
SYNTHESIS, CHARACTERIZATION, AND POLYMERIZATION OF GLYCIDYL METHACRYLATE DERIVATIZED DEXTRAN
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DOI：
10.1021/ma00122a044
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发表时间：
1995-08-28
期刊：
影响因子：
5.5
通讯作者：
HENNINK, WE
中科院分区：
文献类型：
--
作者：
VANDIJKWOLTHUIS, WNE;FRANSSEN, O;HENNINK, WE
以二甲基亚砜（DMSO）为非质子溶剂，在4-（N，N-二甲氨基）吡啶存在下，将葡聚糖与甲基丙烯酸缩水甘油酯（GMA）偶联，合成了dex-GMA衍生物。产物结构经H-1和CH-COSY NMR确证。通过NMR测定的取代度可以通过改变葡聚糖的摩尔数来控制。建立了几乎定量的GMA掺入（>90%）。以过硫酸铵（APS）和N，N，N 'N'-四甲基乙二胺（TEMED）为引发体系，通过dex-GMA水溶液的自由基聚合制备水凝胶。通过FTIR分析测定的聚合速率取决于APS、TEMED和dex-GMA浓度。通过选择合适的聚合条件，可以得到其中超过95%的甲基丙烯酸酯基团在20分钟内反应的水凝胶。
Glycidyl methacrylate derivatized dextran (dex-GMA) was synthesized by coupling of GMA to dextran in the presence of 4-(N,N-dimethylamino)pyridine using DMSO as an aprotic solvent and characterized by GPC, FTIR, and NMR. The structure of the product was established with H-1 and CH-COSY NMR. The degree of substitution, as determined by NMR, can be controlled by varying the molar dextran. Almost quantitative incorporation of GMA (>90%) was established. Hydrogels were prepared by radical polymerization of aqueous solutions of dex-GMA, using ammonium peroxydisulfate (APS) and N,N,N'N'-tetramethylethylenediamine (TEMED) as the initiating system. The polymerization rate, as determined by FTIR analysis, was dependent on the APS, the TEMED, and the dex-GMA concentration. By proper selection of the polymerization conditions, hydrogels could be obtained in which more than 95% of the methacrylate groups had reacted within 20 min.